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Although autograft is a routine procedure in anterior interbody fusion of the cervical spine, donor site morbidity is a significant problem. Many bone grafting materials developed such as allograft bone, demineralized bone matrix (DBM), and synthetic implants were used to repair bony defects; however, each has its specific disadvantage. Therefore, alternative materials for autogenous bone in grafting are needed. Ninety-one patients with symptomatic cervical disc diseases were randomly allocated for either autologous iliac crest bone graft (AIG) or mineralized collagen (MC). Clinical and radiological comparisons were performed for the two groups. Patients were followed-up routinely in the outpatient clinic, where clinical and radiological evaluations were taken. The mean operation time to perform AIG and MC was 194 ± 37 and 121 ± 26 minutes, respectively. The mean volume of blood loss during the operation was 140 ± 41 and 79 ± 25 mL for AIG and MC, respectively. The mean length of hospitalization due to AIG and MC was 9 7 ± 0 7 and 5 9 ± 0 8 days, respectively. The clinical outcomes were identical, and fusion rates were similar between the two groups. This study shows effective results of MC in anterior cervical intersomatic fusion. MC may be a promising substitute for autologous iliac crest bone graft.

Thus, C19 can attenuate airway eosinophilia and lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma. Given its ability to inhibit human CCR3- and CCR4-meditated chemotaxis, C19 has great therapeutic potential for use in the treatment and control of allergic asthma.

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198underwent conventional surgery based on the surgeon's experience. Condyle position and reconstructed mandible contour were evaluated based on postoperative computed tomography. Complications were also evaluated during the follow-up. Findings: Flap success rate of the patients was 95.6% (43/45). Those in the computer-assisted group presented with better outcomes of the mandibular contour (P = 0.001) and condyle position (P = 0.026). Further, they also experienced beneficial dental restoration (P = 0.011) and postoperative appearance (P = 0.028). The difference between postoperative effect and virtual plan was within the acceptable error margin. There is no significant difference in the incidence of postoperative complications. Conclusion: Computer-assisted techniques can improve the clinical outcomes of mandibular reconstruction with vascularised iliac crest flap.http://dx. Background:The use of free fibular flaps and anterolateral thigh (ALT) flaps for repairing the oromandibular defects is well established, whereas few attentions were focused on postoperative analgesia for the donor area. Objective: To evaluate the effect and safety of lower limb blocks in postoperative analgesia for the free flap donor site. Methods: 40 patients with oromandibular defects who were scheduled for elective reconstructive surgery using free fibular or ALT flaps, were divided into two groups in a randomised, singleblind fashion. In Group PCA, only intravenous patient controlled analgesia (PCA) was used postoperatively. In Group PCA + B, both intravenous PCA and lower limb blocks were used. For patients with fibular flaps harvested, femoral nerve block and common peroneal nerve with ropivacaine were administered. For patients with ALT flaps harvested, femoral nerve block with ropivacaine was administered. Pain scores at donor site, monitoring of vital signs, onset and duration of sensory and motor block, the dose of postoperative rescue analgesics and patient satisfaction with pain relief were performed. Results: Pain scores were lower in Group PCA + B. In Group PCA + B, sensory blocks lasted 13.5 ± 4.1 h. Expectations of patients were improved in Group PCA + B. None experienced motor blockade. Lower limb blocks reduced postoperative analgesic requirements. Conclusions: Lower limb blocks may be safe and effective in postoperative analgesia for the donor site of free fibular and ALT flaps. Lower limb blocks also improve patient satisfaction. http://dx.Background: Mandibular reconstruction is one of the cornerstones of oral and maxillofacial surgery. Bone grafting is a favourable option for such reconstruction. Deep circumflex iliac artery terminal musculocutaneous perforator flap with iliac crest is a good choice for oromandibular defect because of its adequate bone and satisfactory soft tissue. Objectives: This study examined oromandibular defects reconstructed using deep circumflex iliac artery perforator flap with iliac crest (DCIAPF). Methods: From November 2015 to August 2016, 23 patients with mandibular defects after oncologi...