Topological materials which are also superconducting are of great current interest, since they may exhibit a non-trivial topologically-mediated superconducting phase. Although there have been many reports of pressure-tuned or chemical-doping-induced superconductivity in a variety of topological materials, there have been few examples of intrinsic, ambient pressure superconductivity in a topological system having a stoichiometric composition. Here, we report that the pure intermetallic CaSn3 not only exhibits topological fermion properties, but also has a superconducting phase at ~1.178 K under ambient pressure. The topological fermion properties, including the nearly zero quasi-particle mass and the non-trivial Berry phase accumulated in cyclotron motions, were revealed from the de Haas-van Alphen (dHvA) quantum oscillation studies of this material. Although CaSn3 was previously reported to be superconducting with Tc =
Mutations in K-ras and p53 are among the most common genetic alterations in non-small cell lung cancer. To determine mechanisms of lung tumorigenesis, we obtained K-ras LA1 mice (developed in the laboratory of T. Jacks, MIT), which develop lung tumors with 100% frequency. To establish the molecular mechanisms of p53 function in the lung epithelium and its relation to neoplastic transformation, we disrupted wild-type p53 activities by transgenically expressing an oncogenic mutant form of human p53 (R175H mutation) specifically in the lung epithelium of mice using the human surfactant protein C (SPC) promoter, SPC-DNp53 mice. The SPC-DNp53 mice were interbred with the K-ras LA1 mice with the expectation of oncogenic cooperativity and lung tumorigenesis. Mice in the C57BL/6 inbred strain of the four possible genotypes (K-ras+/DNp53+, K-ras+, DNp53+, and wild-type) were monitored for the development of lung tumors. The K-ras+/DNp53+ mice displayed multifocal lung tumors with a median survival of 218 days. K-ras+ littermates developed large lung tumors at a lower multiplicity with a median survival of 388 days. DNp53+ and wild-type littermates had a median survival >500 days and did not develop lung tumors. Alveolar hyperplasias with distinct cytology were detected in the K-ras+/DNp53+ and K-ras+ mice by day 80. Recent studies have demonstrated that expression of mutant K-ras in lung epithelial cells elicits inflammation that promotes carcinogenesis in mice. Moreover, our previous results showed that SPC-DNp53 mice displayed exaggerated inflammation after lung injury. Whether or not inflammation is further enhanced during lung tumorigenesis induced by the combination of oncogenic K-ras and mutant p53 has not been determined. Inflammatory cytokine profiles were performed on whole lung extracts at early stages of tumor development (day 55-105) to correlate progression with altered inflammation in the lung. Relative to wild-type, overall inflammatory cytokine levels in lung extracts from mice at early times of tumor progression appeared similar in K-ras+, elevated in DNp53+, and reduced in K-ras+/DNp53+ mice. Assessment of individual cytokines in K-ras+/DNp53+ mice suggested selective reduction of cytokines correlating with a T helper-2 (T h 2) phenotype. Linear regression analyses of cytokine levels versus age (a surrogate for tumor progression) revealed that the levels of only 5 cytokines [IL-12(p40), IL-17, KC, G-CSF and CCL2/MCP-1] increased in K-ras+/DNp53+ mice. Expression of these cytokines corresponds to induction of a T h 17 response and macrophage activation during progression of K-ras+/DNp53+ lung tumors. Relative to their male counterparts, female K-ras+/DNp53+ mice displayed significantly higher levels of T h 1 cytokines. In human lung adenocarcinoma, elevated serum levels of interferon-γ, a marker for the T h 1 phenotype, correlates with a worse prognosis (Surgery 131(1 Suppl):S236-41, 2002). These observations suggest that oncogenic cooperation between K-ras and mutant p53 promotes lung tumorigenesis by mo...
used to estimate the persistence of treatment overall and comparatively between biologics naïve patients and switchers from other biologics. Results: Threehundred-one (103 RA, 122 AS, 76 PsA) patients were followed for 515 patient-years (median 1.24 (IQR 0.5-2.7) years). The proportions of females in RA/AS/PsA groups were 76%/37%/51%. Median ages at golimumab initiation and times from diagnosis to golimumab treatment in RA/AS/PsA groups were 59/49/44 and 6.8/4.8/8.0 years, respectively. Golimumab was the first biologic in 79%/67%/70% of patients with RA/AS/PsA. Amongst RA patients 73%/74% were RF/ACPA positive and 86% of AS patients HLA-B27 positive. The proportions of RA/PsA patients who were on concomitant conventional DMARDs (glucocorticoids) at baseline were 85% (36%)/72% (8%). At the initiation of golimumab mean PromisHAQ was 40/31/39 in RA/AS/PsA; mean DAS28 5.6/5.0 in RA/PsA; mean BASDAI 5.9 in AS group(s). Among patients with measured disease activity at 6 (12) months 47% (59%)/77% (64%) of RA/PsA patients achieved DAS28< 3.2 and 54% (54%) of AS patients achieved at least 2.0 reduction of BASDAI. The proportions of RA/AS/PsA patients discontinuing golimumab treatment overall were 42%/23%/37%. Reasons for discontinuation were ineffectiveness in 68%/89%/71% in RA/AS/PsA. The unadjusted persistence of golimumab treatment for RA/AS/PsA at 6, 12, 24 months was 97%, 82%, 65%/96%, 91%, 73%/97%, 83%, 57%, respectively and did not differ significantly between biologics-naïve patients and switchers. ConClusions: In Slovenia, the persistence of golimumab after 2 years of treatment was 65%/73%/57% in RA/AS/PsA groups. Switcher status seems not to affect the persistence of golimumab regardless of indication.
Iron chalcogenides are of particular interests among iron-based superconductors due to their distinct properties such as high-T c on FeSe monolayer and competing magnetic correlations in Fe1+y Te. Here we report unusual transport properties observed near the critical composition of Fe1+y Te (y ∼ 0.09) where competing magnetic correlations exist. The resistivity exhibits surprising temperature-dependent relaxation behavior below T N, resulting in the increase of resistivity with time for 35 K < T < T N, but the decrease of resistivity with time for 10 K < T < 35 K. Such resistivity relaxation is intimately coupled to the magnetization relaxation and can be attributed to the glassy magnetic states induced by the competing magnetic orders. These findings demonstrate strong coupling between itinerant carriers and local ordered moments in Fe1+y Te.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.