Atracurium is a neuromuscular blocking agent that spontaneously degrades by
Hoffmann reaction. This study of a prolonged infusion (7 days) in an infant of 6 months
shows an increase in infusion rate requirement from 0.7 mg/kg/h after 96 h of infusion to
1.8 mg/kg/h at the 7th day. The plasma laudanosine levels remained relatively constant
(977-1,515 ng/ml) and well below the reported potent convulsive levels during the study
despite a 3-fold increase in the atracurium requirement. No side effect or accumulation of
the drug was observed. The reasons for the increase in atracurium requirement are discussed.
These results indicate that aprotinin at doses currently used to reduce blood loss has no significant influence on the systemic inflammatory response during moderate hypothermic cardiopulmonary bypass in human subjects, as assessed by the mediators measured in this study.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.