Aprotinin does not influence the inflammatory reaction to cardiopulmonary bypass in humans

Schmartz, Denis; Tabardel, Y; Preiser, J.-C.; Barvais, Luc; d'Hollander, A.; Duchateau, Jean; Leclerc, Jean Louis; Vincent, Jean‐Louis

doi:10.1186/cc321

Cited by 4 publications

(4 citation statements)

References 2 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several therapeutic aspects have been proposed to modulate the inflammatory response, such as hemofiltration [12] or the use of various pharmacological agents, including steroids [17], nonsteroidal anti-inflammatory drugs [28], pentoxyphylline [5], aprotinin [22], or complement receptor blocking agents [2]. Although steroids have been used for years to attenuate post-bypass inflammation, data to support this derive almost entirely from trials in adults with coronary artery disease.…”

mentioning

confidence: 99%

Administration of Steroids in Pediatric Cardiac Surgery: Impact on Clinical Outcome and Systemic Inflammatory Response

Gessler¹,

Hohl²,

Carrel

et al. 2005

Pediatr Cardiol

View full text Add to dashboard Cite

Abstract. Cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response. Pre-bypass steroid administration may modulate the inflammatory response, resulting in improved postoperative recovery. We performed a prospective study in the departments of cardiovascular surgery and pediatric intensive care medicine of two university hospitals that included 50 infants who underwent heart surgery. Patients received either prednisolone (30 mg/ kg) added to the priming solution of the cardiopulmonary bypass circuit (steroid group) or no steroids (nonsteroid group). Clinical outcome parameters include therapy with inotropic drugs, oxygenation, blood lactate, glucose, and creatinine, and laboratory parameters of inflammation include leukocytes, C-reactive protein, and interleukin-8. Postoperative recovery (e.g., the number, dosage, and duration of inotropic drugs as well as oxygenation) was similar in patients treated with or without steroids when corrected for the type of cardiac surgery performed. After CPB, there was an inflammatory reaction, especially in patients with a long CPB time. Postoperative plasma levels of interleukin-8 were correlated with the duration of CPB time (r = 0.62, p < 0.001). Administration of steroids had no significant impact on the laboratory parameters of inflammation. Administration of prednisolone into the priming solution of the CPB circuit had no measurable influence on postoperative recovery and did not suppress the inflammatory response.

show abstract

mentioning

confidence: 99%

Administration of Steroids in Pediatric Cardiac Surgery: Impact on Clinical Outcome and Systemic Inflammatory Response

Gessler¹,

Hohl²,

Carrel

et al. 2005

Pediatr Cardiol

View full text Add to dashboard Cite

show abstract

“…Another extensively studied feature of aprotinin is its anti‐inflammatory action. While no significant influence on the systemic inflammatory response was found in adults during moderate hypothermic cardiopulmonary bypass, as assessed by the plasma concentration of the tumor necrosis factor, interleukins, complement factors, and other blood markers of inflammation (70), there is some evidence in the neonatal study groups that with high‐dose aprotinin the inflammatory response is attenuated, and the postoperative course may be better (65).…”

Section: Other Techniques Limiting Allogenic Blood Transfusion In Chimentioning

confidence: 99%

How to limit allogenic blood transfusion in children

Wołoszczuk-Gębicka

2005

Pediatric Anesthesia

View full text Add to dashboard Cite

“…Another protease inhibitor, urinary trypsin inhibitor (UTI), has been shown to protect against bacterial endotoxin‐induced systemic inflammatory response and subsequent organ injury [12] and acute lung injury [13] through preventing expression of pro‐inflammatory cytokines and chemokines. However, the anti‐inflammatory effect of BPTI in patients with cardiopulmonary bypass surgery is controversial [14–17] …”

Section: Introductionmentioning

confidence: 99%

Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice

Yang

Dong

Fang

et al. 2010

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

Aprotinin does not influence the inflammatory reaction to cardiopulmonary bypass in humans

Cited by 4 publications

References 2 publications

Administration of Steroids in Pediatric Cardiac Surgery: Impact on Clinical Outcome and Systemic Inflammatory Response

Administration of Steroids in Pediatric Cardiac Surgery: Impact on Clinical Outcome and Systemic Inflammatory Response

How to limit allogenic blood transfusion in children

Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice

Contact Info

Product

Resources

About