Some New 3-Substituted-4-amino-5-mercapto-4(H)-1,2,4-triazoles as Nonsteroidal Antiinflammatory Agents.-The title triazoles (III) exhibit significant antiinflammatory activity comparable with that of the standard ibuprofen and they show a smaller degree of ulcerogenity. The synthesized compounds also exhibit good to moderate antimicrobial activity against the tested bacteria and fungi. The triazole (IIIb) exhibits antituberculosis activity against M. tuberculosis H37Rv strain.-(LADDI, U. V.; DESAI, S. R.; SOMANNAVAR, Y. S.; BENNUR, R. S.; BENNUR, S. C.; Indian J.
A new unknown impurity of cefoxitin formed during a gradient reverse phase high performance liquid chromatography (HPLC) analysis of stress stability samples of the drug substance cefoxitin, and the level of this impurity was found at up to 0.9%. This impurity was identified by LC-MS and characterized by ( 1 H NMR, 13 C NMR, LC/MS/MS, elemental analysis and FT-IR). Based on the spectral data, the impurity was named as, 3-[[(2R,3S)-[3-methoxy-3-N-[2-(thiophen-2-yl)acetamido]]-4oxoazetidin-2-ylthio]-2-[(carbamoyloxy)methyl]]-acrylic acid. The structure of this impurity was also established unambiguously, prepared by isolation and co-injected into HPLC to confirm the retention time. To the best of our knowledge, this impurity has not been reported elsewhere. Structural elucidation of the impurity by spectral data is discussed in detail.
can be synthesized starting from commercially available vanillin and isovanillin, respectively. -(SENTHILKUMAR, N.; SOMANNAVAR, Y. S.; REDDY*, S. B.; SINHA, B. K.; NARAYAN, G. K. A. S. S.; DANDALA, R.; MUKKANTI, K.; Synth. Commun. 41 (2011) 2, 268-276, http://dx.
This work reports the feasibility of recently developed industrial viable process for eltrombopag olamine
starting from 2-bromo-6-nitro phenol and reports the identification of four potential impurities related
to eltrombopag olamine, namely eltrombopag olamine ester (1), 2-aminophenol analogue of
eltrombopag (2), 3,3′-(2-amino-3-oxo-3H-phenoxazine-4,6-diyl dibenzoic acid (3), 2′-hydroxy[1,1-
biphenyl]-3-carboxylic acid (4). These impurities are the crucial components in determining the quality
of the drug substance, eltrombopag olamine during its manufacturing. These impurities have impact
on the quality of eltrombopag olamine and controlled these impurities results excellent yields of active
pharma ingredient of eltrombopag olamine
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