ChemInform Abstract: Some New 3‐Substituted‐4‐amino‐5‐mercapto‐4(H)‐1,2,4‐triazoles as Nonsteroidal Antiinflammatory Agents.

Abstract

Some New 3-Substituted-4-amino-5-mercapto-4(H)-1,2,4-triazoles as Nonsteroidal Antiinflammatory Agents.-The title triazoles (III) exhibit significant antiinflammatory activity comparable with that of the standard ibuprofen and they show a smaller degree of ulcerogenity. The synthesized compounds also exhibit good to moderate antimicrobial activity against the tested bacteria and fungi. The triazole (IIIb) exhibits antituberculosis activity against M. tuberculosis H37Rv strain.-(LADDI, U. V.; DESAI, S. R.; SOMANNAVAR, Y. S.; BENNUR, R. S.; BENNUR, S. C.; Indian J.

Some chalcones derived from thiophene-3-carbaldehyde: synthesis and crystal structures

“…Thiophene, C 4 H 4 S, belongs to a class of aromatic fivemembered heterocycles containing one S heteroatom. Many thiophene derivatives exhibit biological activities: antibacterial (Mishra et al, 2012), antiallergic (Gillespie et al, ISSN 2056-9890 1985), analgesic (Laddi et al, 1998), and act as anti-inflammatory agents (Ferreira et al, 2006), antioxidant agents (Jarak et al, 2005) and antitumor agents (Gadad et al, 1994). With the introduction of a thiophene ring into chalcones, it was hoped to design chalcones with interesting new structures and properties.…”

The synthesis, crystal structure and Hirshfeld surface analysis of the thiophene derivatives 5-(phenylsulfonyl)-5,6-dihydrobenzo[4,5]thieno[3,2-j]phenanthridine and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]phenyl}-N-(prop-2-yn-1-yl)benzenesulfonamide

“…Thiophene, C 4 H 4 S, belongs to a class of aromatic fivemembered heterocycles comprising one S heteroatom. Thiophene derivatives possess pharmacological and biological activities including antibacterial (Mishra et al, 2012), antiallergic (Gillespie et al,1985), anti-cancer and anti-toxic (Gewald et al, 1966), analgesic (Laddi et al, 1998;Chen et al, 2008), anti-inflammatory (Ferreira et al, 2006), antioxidant (Jarak et al, 2005), antitumor (Gadad et al, 1994), antimicrobial (Abdel-Rahman et al, 2003), antihypertensive (Monge Vega et al, 1980), anti-diabetes mellitus (Abdelhamid et al, 2009), gonadotropin releasing hormone antagonist (Sabins et al, 1944) and are building blocks in many agrochemicals (Ansary & Omar, 2001). Thiophene possesses promising pharmacological activities, such as anti-HIV PR inhibitor (Bonini et al, 2005) and anti-breast cancer (Brault et al, 2005).…”

Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide

“…Thiophene, C 4 H 4 S, belongs to a class of aromatic fivemembered heterocycles comprising one S heteroatom. Thiophene derivatives possess pharmacological and biological activities including antibacterial (Mishra et al, 2012), antiallergic (Gillespie et al, 1985), anti-cancer and anti-toxic (Gewald et al, 1966), analgesic (Laddi et al, 1998;Chen et al, 2008), anti-inflammatory (Ferreira et al, 2006), antioxidant (Jarak et al, 2005), antitumor (Gadad et al, 1994), antimicrobial (Abdel-Rahman et al, 2003), antihypertensive (Monge Vega et al, 1980), anti-diabetes mellitus (Abdelhamid et al, 2009), gonadotropin releasing hormone antagonist (Sabins et al, 1944) and they are building blocks in many agrochemicals (Ansary & Omar, 2001). Thiophene possesses promising pharmacological activities, such as anti-HIV PR inhibitor (Bonini et al, 2005) and anti-breast cancer (Brault et al, 2005).…”