We have performed for the first time the simultaneous measurement of the two-body and threebody photodisintegration cross-sections of 4 He in the energy range from 21.8 to 29.8 MeV using monoenergetic pulsed photons and a 4π time projection chamber containing 4 He gas as an active target in an event-by-event mode. The photon beam was produced via the Compton backscattering of laser photons with high-energy electrons. The 4 He(γ,p) 3 H and 4 He(γ,n) 3 He cross sections were found to increase monotonically with energy up to 29.8 MeV, in contrast to the result of a recent theoretical calculation based on the Lorentz integral transform method which predicted a pronounced peak at around 26−27 MeV. The energy dependence of the obtained 4 He(γ,n) 3 He cross section up to 26.5 MeV is marginally consistent with a Faddeev-type calculation predicting a flat pattern of the excitation function. The cross-section ratio of 4 He(γ,p) 3 H to 4 He(γ,n) 3 He is found to be consistent with the expected value for charge symmetry of the strong interaction within the experimental uncertainty in the measured energy range. The present results for the total and two-body crosssections of the photodisintegration of 4 He are compared to previous experimental data and recent theoretical calculations.

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Olfactory information is conveyed from the periphery to the olfactory cortices through mitral and tufted (M/T) cells in the olfactory bulb. A mouse with a specific expression of Cre recombinase in M/T cells is essential for genetic marking of M/T cells and manipulating their properties. Protocadherin 21 (Pcdh21) expression is highly restricted to M/T cells. Here we report a transgenic mouse line, Pcdh21-Cre, in which 10-kb mouse Pcdh21 promoter drives the expression of Cre recombinase. In Pcdh21-Cre mice, Cre recombinase activity is predominantly detected in M/T cells, visualized with the anti-CFP immunostaining in offspring of a cross between Pcdh21-Cre and the reporter Rosa26-loxP-stop-loxP-CFP strain. These results demonstrate that the 10-kb Pcdh21 promoter can drive transcription in M/T cells and Pcdh21-Cre mice can be used to excise floxed DNA fragments in M/T cells, which provides a valuable tool to reveal the structure and function of the central olfactory circuits.

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