SUMMARYThe possible occurrence of DIC in active systemic anaphylaxis was investigated in mice. Induction of active systemic anaphylaxis resulted in the development of DIC symptoms such as thrombocytopenia. prolongation of prothrombin time, hypofibrinogaemia, and elevated level of fibrinogen/fibrin degradation products. In addition, in histologica! examinations, massive congestion and cellular infiltration in pulmonary interstitia, and considerable haemorrhage in renal medullae were observed. All these changes were nearly completely prevented by pretreatment with platelet-activating factor (PAF) antagonist (BN 50739). Moreover, the same haematological and morphological changes were produced by a bolus injection of PAF. These data strongly suggest that DIC occurs in active systemic anaphylaxis and PAF plays a pivotal role in the development of Die in anaphylaxis.
Photodynamic therapy (PDT) is a treatment option for acne patients who fail to respond to conventional therapy. Although potent, we experience side effects such as erythema, exfoliation and dyspigmentation. In attempt to specify treatment and shorten the incubation time, we injected 5-aminolevulinic acid (ALA) to the individual lesion. The results of intralesional injection ILI-PDT and conventional PDT are compared in this study.
MPA promotes proliferation of DPCs and induction of anagen hair follicles in mice. This finding raises the possibility that MPA could be used as a treatment option for hair-loss disorders.
Glioblastoma is a devastating brain tumor with dismal prognosis of only 15-month survival regardless of surgical resection with few alternatives. Here, we report a reactive astrogliosis-targeted neuroimaging technique using the fusion of 11C-acetate PET and MRI (AcePET) extended the overall survival of patients by 5.25 months compared to conventional MRI-guided surgery. Targeted biopsy of 11C-acetate uptake-increased regions showed the signs of reactive astrogliosis with cancer stem cells at the boundary of high-grade gliomas. The appearance of marginal reactive astrogliosis and MCT1-dependent 11C-acetate uptake was recapitulated in U87MG-orthotophic models. U87MG-derived excessive glutamate caused reactive astrogliosis and aberrant astrocytic GABA-release, which subsequently reduced neuronal glucose uptake through glucose transporter-3 (GLUT3). We propose AcePET-guided surgery, visualizing reactive astrogliosis, as an advanced surgical strategy to improve glioblastoma patient survival.
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