The tumor-free surgical margin was important to survival. When T4 lesions did not involve the pyramidal apex, carotid canal, dura, or any lymph nodes, the surgical intervention improved the estimated survival rate to a level as good as T3 lesions.

Decreased maspin expression may be a significant factor associated with the metastatic potential of stage I and II oral tongue SCCs.

No abstract

Salvage pharyngolaryngectomy and jejunal transfer can be performed safely and reliably for patients with locally recurrent hypopharyngeal carcinoma, and it is an excellent option after a failure of definitive chemoradiotherapy.

Because a high rate of laryngeal preservation was achieved without compromising disease-specific survival, our treatment approach based on FAR therapy may be promising for the treatment of patients with T2N0 glottic carcinoma.

We report clinical experience in managing a 46-year-old Japanese man with long-standing nasal obstruction resulting from a huge left nasal mass. Computed tomography, magnetic resonance imaging and biopsy were used to make a provisional diagnosis of inverted papilloma. The mass was resected via a frontal approach combined with rhinotomy. Histopathologic examination of the resected specimen was consistent with a hamartoma that included an inverted papilloma on a portion of its surface. In addition to being rare tumors in the nasal cavity, we believe that our patient's tumor the largest nasal hamartoma ever reported.

Magnetoencephalography (MEG) is a procedure that analyzes the magnetic responses of neurons. An MEG system with a 37-channel superconductivity quantum interference device (SQUID) was used to record magnetic signals from the human brain in response to tactile stimulations of the face and oral cavity. Six normal individuals were studied as well as three patients who had undergone hemiglossectomies as treatment for carcinoma of the tongue and reconstruction with a pectoralis major myocutaneous flap. When the locations of the magnetic responses having latencies of 40 ms from onset of tactile stimulation were identified, these corresponded to the primary somatosensory cortex. In patients whose tongues had been reconstructed with a pectoralis major myocutaneous flap, the magnetic response upon stimulation of the flap was recorded in a sensory cortical area identical to that corresponding to the tongue. MEG systems such as the one described permit functional mapping of the cerebral cortex on stimulating the face and oral cavity.

There is no standard reconstructive technique for cancer ablation in head and neck lesions. The wide variety of reconstructive techniques results in big differences in outcomes among each institution, so we carried out a multi-institutional study of reconstructive techniques, and investigated the outcomes for 10 years.In order to standardize the range of ablation, only patients who had a reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were included in this study. 764 patients were enrolled, of whom 715 patients (93.7%) were reconstructed with jejunum. There were differences among each institution's situation regarding the ratio of preoperative radiation and chemotherapy, total operation time, total volume of bleeding, ratio of abscess formation and fistula formation, duration of fast and hospital stay after operation.There was a correlation between long operation time and much bleeding. There was also a correlation between a large number of operations and short operation time. There was no correlation between the use of PGE1 and the risk of thrombosis. Preoperative radiation delayed wound healing significantly. We studied a multivariate analysis on each factor. The use of penrose drain and long operation time were significant risk factors of abscess or fistula formation. Based on these results, we would like to standardize reconstructive technique.