Our results show that as renal function deteriorates in glomerulopathy the nocturnal dip in blood pressure is lost, resulting in enhanced urinary sodium and protein excretions during night. These findings are compatible with our proposal that impaired natriuresis during daytime makes nocturnal blood pressure elevated to compensate for diminished natriuresis by pressure natriuresis. We speculate that nocturnal glomerular capillary hypertension contributes, at least in part, to enhanced urinary sodium and protein excretions during night.

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The 800-ton cosmic-ray spectrograph (MUTRON) has been used to measure the sea-level energy spectrum of cosmic-ray muons arriving from 86" to 90" zenith angles in the momentum region of 100-20000 GeV/c. The measured muon energy spectrum can be interpreted by using a cosmic-ray primary spectrum of (1.80 ~m -~s -' s r -' G e~-' )~-~~~~d~ (E in GeV) and a scaling model incorporating an increasing interaction cross section for meson production in hadron-hadron interaction. The muon charge ratio at energies up to 15 TeV in the same zenith-angle range has been measured. It shows a small enhancement with increasing energy. By combining both results we may conclude that the cosmic-ray primary particle composition stays the same up to about 100 TeV as that obtained by direct measurements in the energy range below 1 TeV.

The renal protective effects of ACE inhibitors have been established by results with animal models of progressive nephropathy and large-scale clinical trials. Our epidemiologic results for Japan as a whole show the same protective effects still more convincingly from a different approach.

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Abstract. Ascites caused by hypothyroidism is rare and the pathogenesis is unclear. Several reports have presented cases of progressive ascites with hypothyroidism and elevated tumor markers. We report a 31-year-old female case with massive ascites and elevated serum CA 125 concentrations. The patient had no typical feature of hypothyroidism except an accumulation of ascitic fluid which showed elevated total protein concentration and a high serum-ascites albumin gradient (SAAG). There was no finding of malignancy. Following thyroid hormone replacement, the ascites was completely resolved accompanied by reduced concentrations of serum CA125. In general, primary hypothyroidism with ascites presents with coexisting massive pericardial or pleural effusion. The massive ascites and increased serum CA125 concentrations may have led us to make the incorrect diagnosis of ovarian malignancy. The evaluation of thyroid function is useful to determine the pathology of high-protein ascites or elevated tumor markers, and ascites may be treatable by thyroid replacement therapy.

Abstract.We encountered a case with long