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This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative νe rates and energy spectra variation among the near and far detectors gives sin 2 2θ13 = 0.0759 +0.0050 −0.0049 and ∆m 2 32 = (2.72 +0.14 −0.15 )× 10 −3 eV 2 assuming the normal neutrino mass ordering, and ∆m 2 32 = (−2.83 +0.15 −0.14 )×10 −3 eV 2 for the inverted neutrino mass ordering. This estimate of sin 2 2θ13 is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields sin 2 2θ13 = 0.0833 ± 0.0022, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result.

The Daya Bay experiment was the first to report simultaneous measurements of reactor antineutrinos at multiple baselines leading to the discovery ofν e oscillations over km-baselines. Subsequent data has provided the world's most precise measurement of sin 2 2θ 13 and the effective mass splitting ∆m 2 ee . The experiment is located in Daya Bay, China where the cluster of six nuclear reactors is among the world's most prolific sources of electron antineutrinos. Multiple antineutrino detectors are deployed in three underground water pools at different distances from the reactor cores to search for deviations in the antineutrino rate and energy spectrum due to neutrino mixing. Instrumented with photomultiplier tubes, the water pools serve as shielding against natural radioactivity from the surrounding rock and provide efficient muon tagging. Arrays of resistive plate chambers over the top of each pool provide additional muon detection. The antineutrino detectors were specifically designed for measurements of the antineutrino flux with minimal systematic uncertainty. Relative detector efficiencies between the near and far detectors are known to better than 0.2%. With the unblinding of the final two detectors' baselines and target masses, a complete description and comparison of the eight antineutrino detectors can now be presented. This paper describes the Daya Bay detector systems, consisting of eight antineutrino detectors in three instrumented water pools in three underground halls, and their operation through the first year of eight detector data-taking.

We have tested a published algorithm for pharmacokinetic model controlled infusion of propofol to supplement 67% nitrous oxide for general anaesthesia in Chinese children aged 4-10 yr. Initially we studied 10 children undergoing minor procedures with spontaneous ventilation; mean duration of surgery was 38 min and mean propofol infusion rate 497 micrograms kg-1 min-1. The precision of the model was 24.8% and bias -18.5%. The model was revised using an iterative linear least squares regression procedure and the revised model tested prospectively in another 20 children. The precision of the revised model was 21.5% (range in individuals 8.4-43.1%) and bias -0.1% (range -30 to 42%). Mean propofol infusion rate required to maintain anaesthesia was 474 micrograms kg-1 min-1 (range 125-737 micrograms kg-1 min-1). The mean blood concentration required for satisfactory anaesthesia was 6.6 micrograms ml-1 (range 3-11 micrograms ml-1) and the mean blood concentration at the time of waking, which occurred 40 min after switching off the infusion, 0.86 microgram ml-1 (range 0.40-1.45 micrograms ml-1). Our patient population required different pharmacokinetic variables from those in the previous study. Recovery was slow because of the high infusion rates required to maintain satisfactory anaesthesia and large difference between the blood concentration required for anaesthesia and that at which waking occurred.