These results indicate that impaired HS in COPD is related to the peripheral muscle changes characterized by less type I fibers proportion. The findings argue in favor of an important contribution of the systemic consequences on the HS in COPD independently from the airflow limitation severity, and help to explain the observation of the poor correlation between the degree of airflow limitation and SGRQ total score.

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Efecto gelificante del agar de Gracilaria debilis en la elaboración de una compota de níspero (Manilkara zapota)Gelling effect of Gracilaria debilis agar in the elaboration of a sapodilla (Manilkara zapota) compote

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The computational modeling using integral methods of dynamic loading and its effects on the nutrients transport in spine discs is addressed in this work. The numerical simulation and analysis was carried out using the Boundary Element Method (BEM) and a 3D model (axisymmetric) of the disc. The boundary model was discretized using linear interpolated elements and a multi-region approach. Concentration and production of three nutrients as lactate, oxygen and glucose were obtained. The maximum lactate concentration was observed very close to the interface between the nucleus and the inner annulus. A relatively simple model discretized with 130 boundary elements yielded very similar results to these coming from more complex FEM-based models. The numerical efforts in the domain and boundary discretizations were optimized using the BEM. Our results are in good agreement with those obtained using with finite element-based models. As expected, the dynamic loading increased the oxygen–glucose consumption and the lactate production, thus leading to a poor oxygen–glucose concentration at the nucleus of the disc. All of that is a favorable environment for a disc degeneration mechanism to be developed.

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