Peripheral muscle composition and health status in patients with COPD

de, María Montes; Torres, Sonia H.; González, Y.; Romero, E.; Hernández, Noelina; Mata, Abdón; Tálamo, Carlos

doi:10.1016/j.rmed.2006.01.020

Cited by 42 publications

(27 citation statements)

References 32 publications

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“…One additional publication, of which we were aware, incorrectly did not appear in the search results because fibre typing was not mentioned in the abstract 6. Of these 39 papers, 20 were excluded for the following reasons: 15 were false positive hits (eg, fibre type proportions were not studied or they were studied in skeletal muscles other than the quadriceps femoris), 2 had overlapping data (Montes de Oca et al 7 8 and Gosker et al 9 10) and 3 because of co-morbidity 6 11 12. The remaining 19 articles were included in the current study (table 1), all biopsies being obtained from the vastus lateralis.…”

Section: Resultsmentioning

confidence: 99%

Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis

Gosker

Zeegers

Wouters

et al. 2007

Thorax

245

176

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Background: Skeletal muscle dysfunction is a common feature in chronic obstructive pulmonary disease (COPD) which is associated with intrinsic muscular abnormalities. One of the most consistently reported alterations is a shift from fibre type I to II in the vastus lateralis of these patients. Surprisingly, the relationship between this shift and the severity and phenotype of COPD remains unclear. A study was conducted to determine whether vastus lateralis muscle fibre type proportions are associated with COPD disease severity and to provide reference values for the proportions of fibre types in the vastus lateralis in COPD. Methods: A systematic review and a meta-analysis were conducted in which muscle fibre type data and markers of disease severity were collected from the literature. Results: The forced expiratory volume in 1 s (FEV 1 ), the ratio of FEV 1 to forced vital capacity (FVC) and body mass index were positively associated with the proportion of type I fibres in COPD. A proportion of 51% for vastus lateralis fibre type I and 13% for fibre type IIX were calculated from the combined data as normal values for patients with typical GOLD stage 3-4 COPD aged 60-70 years. Based on these reference values, a proportion of fibre type I ,27% and of fibre type IIX .29% were defined as pathologically abnormal. Conclusions: This review sheds new light on the relationship between skeletal muscle abnormalities and important hallmarks of the disease in severe COPD, and identifies absence of data in GOLD stages 1-2. This review also provides reference values on fibre type composition for diagnostic purposes in COPD.

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Section: Resultsmentioning

confidence: 99%

Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis

Gosker

Zeegers

Wouters

et al. 2007

Thorax

245

176

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“…Data from human studies clearly indicate that atrophy of skeletal muscles is apparent in COPD and is specific to muscle fibre type IIA/IIx [72]. Furthermore, these abnormalities are related to respiratory function, exercise intolerance, health status, mortality and healthcare resource utilisation [73]. Muscle wasting is associated with loss of muscle strength, which in turn is a significant determinant of exercise capacity in patients with COPD independent of disease severity.…”

Section: Muscle Dysfunction and Malnutrition In Copdmentioning

confidence: 99%

Systemic manifestations and comorbidities of COPD

Barnes¹,

Celli²

2009

European Respiratory Journal

1,465

1,113

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Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow obstruction. Airflow obstruction has profound effects on cardiac function and gas exchange with systemic consequences. In addition, as COPD results from inflammation and/or alterations in repair mechanisms, the ''spill-over'' of inflammatory mediators into the circulation may result in important systemic manifestations of the disease, such as skeletal muscle wasting and cachexia. Systemic inflammation may also initiate or worsen comorbid diseases, such as ischaemic heart disease, heart failure, osteoporosis, normocytic anaemia, lung cancer, depression and diabetes. Comorbid diseases potentiate the morbidity of COPD, leading to increased hospitalisations, mortality and healthcare costs. Comorbidities complicate the management of COPD and need to be evaluated carefully. Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. Treatment of COPD inflammation may concomitantly treat systemic inflammation and associated comorbidities. However, new broad-spectrum anti-inflammatory treatments, such as phosphodiesterase 4 inhibitors, have significant side-effects so it may be necessary to develop inhaled drugs in the future. Another approach is the reversal of corticosteroid resistance, for example with effective antioxidants. More research is needed on COPD comorbidities and their treatment.

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“…Several studies have shown that the function and structure of skeletal muscle are altered in COPD patients and these abnormalities are related to respiratory function, exercise intolerance, health status, mortality and the utilization of healthcare resources [7,8,9]. Muscle wasting is associated with a loss of muscle strength and has therefore been identified as a significant determinant of mortality in COPD, independent of lung function, smoking and BMI [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Muscle wasting is associated with a loss of muscle strength and has therefore been identified as a significant determinant of mortality in COPD, independent of lung function, smoking and BMI [7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic Assessment of the Diaphragm in Chronic Obstructive Pulmonary Disease Patients: Relationships with Pulmonary Function and the Influence of Body Composition - A Pilot Study

et al. 2014

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Background: Skeletal muscle weakness with loss of fat-free mass (FFM) is one of the main systemic effects of chronic obstructive pulmonary disease (COPD). The diaphragm is also involved, leading to disadvantageous conditions and poor contractile capacities. Objectives: We measured the thickness of the diaphragm (TD) by ultrasonography to evaluate the relationships between echographic measurements, parameters of respiratory function and body composition data. Methods: Thirty-two patients (23 males) underwent (1) pulmonary function tests, (2) echographic assessment of TD in the zone of apposition at various lung volumes, i.e. TD at residual volume (TDRV), TD at functional residual capacity (TDFRC) and TD at total lung capacity (TDTLC), and (3) bioelectrical body impedance analysis. The BMI and the BODE (BMI-Obstruction-Dyspnea-Exercise) index values were reported. Results: TDRV, TDFRC and TDTLC measured 3.3, 3.6 and 6 mm, respectively, with good intraobserver reproducibility (0.97, 0.97 and 0.96, respectively). All the TDs were found to be related to FFM, with the relationship being greater for TDFRC (r² = 0.39 and p = 0.0002). With regard to lung volumes, inspiratory capacity (IC) was found to be closely related to TDTLC (r² = 0.42 and p = 0.0001). The difference between TDTLC and TDRV, as a thickening value (TDTLCRV), was closely related to FVC (r² = 0.34 and p = 0.0004) and to air-trapping indices (RV/TLC, FRC/TLC and IC/TLC): the degree of lung hyperinflation was greater and the TDTLCRV was less. Finally, we found a progressive reduction of both thicknesses and thickenings as the severity of IC/TLC increased, with a significant p value for the trend in both analyses (p = 0.02). Conclusions: Ultrasonographic assessment of the diaphragm could be a useful tool for studying disease progression in COPD patients, in terms of lung hyperinflation and the loss of FFM.

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Peripheral muscle composition and health status in patients with COPD

Cited by 42 publications

References 32 publications

Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis

Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis

Systemic manifestations and comorbidities of COPD

Ultrasonographic Assessment of the Diaphragm in Chronic Obstructive Pulmonary Disease Patients: Relationships with Pulmonary Function and the Influence of Body Composition - A Pilot Study

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