Recent years have witnessed a significant advancement in brain imaging techniques that offer a non-invasive approach to mapping the structure and function of the brain. Concurrently, generative artificial intelligence (AI) has experienced substantial growth, involving using existing data to create new content with a similar underlying pattern to real-world data. The integration of these two domains, generative AI in neuroimaging, presents a promising avenue for exploring various fields of brain imaging and brain network computing, particularly in the areas of extracting spatiotemporal brain features and reconstructing the topological connectivity of brain networks. Therefore, this study reviewed the advanced models, tasks, challenges, and prospects of brain imaging and brain network computing techniques and intends to provide a comprehensive picture of current generative AI techniques in brain imaging. This review is focused on novel methodological approaches and applications of related new methods. It discussed fundamental theories and algorithms of four classic generative models and provided a systematic survey and categorization of tasks, including co-registration, super-resolution, enhancement, classification, segmentation, cross-modality, brain network analysis, and brain decoding. This paper also highlighted the challenges and future directions of the latest work with the expectation that future research can be beneficial.
In recent years, human activity recognition (HAR) technologies in e-health have triggered broad interest. In literature, mainstream works focus on the body's spatial information (i.e. postures) which lacks the interpretation of key bioinformatics associated with movements, limiting the use in applications requiring comprehensively evaluating motion tasks' correctness. To address the issue, in this article, a Wearables-based Multi-column Neural Network (WMNN) for HAR based on multi-sensor fusion and deep learning is presented. Here, the Tai Chi Eight Methods were utilized as an example as in which both postures and muscle activity strengths are significant. The research work was validated by recruiting 14 subjects in total, and we experimentally show 96.9% and 92.5% accuracy for training and testing, for a total of 144 postures and corresponding muscle activities. The method is then provided with a human-machine interface (HMI), which returns users with motion suggestions (i.e. postures and muscle strength). The report demonstrates that the proposed HAR technique can enhance users' self-training efficiency, potentially promoting the development of the HAR area.
The topological connectivity information derived from the brain functional network can bring new insights for diagnosing and analyzing dementia disorders. The brain functional network is suitable to bridge the correlation between abnormal connectivities and dementia disorders. However, it is challenging to access considerable amounts of brain functional network data, which hinders the widespread application of data-driven models in dementia diagnosis. In this study, a novel distribution-regularized adversarial graph auto-Encoder (DAGAE) with transformer is proposed to generate new fake brain functional networks to augment the brain functional network dataset, improving the dementia diagnosis accuracy of data-driven models. Specifically, the label distribution is estimated to regularize the latent space learned by the graph encoder, which can make the learning process stable and the learned representation robust. Also, the transformer generator is devised to map the node representations into node-to-node connections by exploring the long-term dependence of highly-correlated distant brain regions. The typical topological properties and discriminative features can be preserved entirely. Furthermore, the generated brain functional networks improve the prediction performance using different classifiers, which can be applied to analyze other cognitive diseases. Attempts on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset demonstrate that the proposed model can generate good brain functional networks. The classification results show adding generated data can achieve the best accuracy value of 85.33%, sensitivity value of 84.00%, specificity value of 86.67%. The proposed model also achieves superior performance compared with other related augmented models. Overall, the proposed model effectively improves cognitive disease diagnosis by generating diverse brain functional networks.
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