No abstract

Background Structural variations (SVs; defined as DNA variants ≥ 50 base pairs) have been associated with various complex human diseases. However, research to screen the whole genome for SVs predisposing to psoriasis is lacking. Objectives To investigate the association of SVs and psoriasis. Methods Using imputation, we performed a genome-wide screen of SVs on five independent cohorts with 45 386 participants from the Han Chinese population.

The level and theodolite are used in the calibrator of the current automobile headlamp tester to align the optical axis center, this method needs many people to cooperate with the operation, the low degree of automation is insufficient. To solve the problem, this paper presents an automatic alignment device and method for calibrator optical axis of vehicle headlamp tester, introduces the structure, composition and principle of the alignment device and the specific implementation methods and steps. The comparison of experimental data shows that the alignment device has the advantages of high automation, simple operation and high accuracy. It can replace the existing level and theodolite to ensure the alignment of the luminous optical axis center of calibrators for headlamp tester of motor vehicle and the geometric center of the illuminometer probe.