Amplitude of low-frequency fluctuation (ALFF) and fractional ALFF in migraine patients: a resting-state functional MRI study

Wang, Jingjie; Chen, Xuesong; Sah, Shambhu Kumar; Zeng, Chun; Li, Y.-m.; Li, N.; Liu, M.-q.; Du, Silin

doi:10.1016/j.crad.2016.03.004

Cited by 81 publications

(90 citation statements)

References 36 publications

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“…To this extent, there are currently Ͼ50 pain imaging studies in which a clear activation signal is seen in the cerebellum (for review, see Moulton et al, 2010), and a few animal studies in which nociceptive stimuli applied to several body regions and organs trigger distinct activation of cerebellar neurons (Ekerot et al, 1987a,b;Ness et al, 1998;Saab and Willis, 2001). If migraine headache alters cerebellar function (Wang et al, 2016) in a way that is similar to the way it is thought to alter sensory processing in the cerebral cortex (May, 2003;Sprenger and Borsook, 2012), or if cerebellar neurons are not spared of the genetic tendency toward neuronal hyperexcitability of the migraine brain (Vincent and Hadjikhani, 2007), it may be reasonable to speculate that abnormally hyperexcitable cerebellar cortex can contribute to activation of meningeal nociceptors in a way shown previously at the cerebral cortex (Zhang et al, 2010(Zhang et al, , 2011. Along this line, it is worthy of our attention to consider the possibility that common cerebellar-mediated migraine symptoms such as vertigo, motion sickness, decreased motor coordination, balance change, and nystagmus (Kuritzky et al, 1981;Toglia et al, 1981;Kayan and Hood, 1984;Cutrer and Baloh, 1992;Cho et al, 1995;Baloh, 1997;Sándor et al, 2001;Ishizaki et al, 2002;Harno et al, 2003;Vincent and Hadjikhani, 2007) may coincide more closely with occipital than frontal migraine headaches.…”

Section: Discussionmentioning

confidence: 99%

Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache

et al. 2019

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Current understanding of the origin of occipital headache falls short of distinguishing between cause and effect. Most preclinical studies involving trigeminovascular neurons sample neurons that are responsive to stimulation of dural areas in the anterior 2/3 of the cranium and the periorbital skin. Hypothesizing that occipital headache may involve activation of meningeal nociceptors that innervate the posterior 1 ⁄3 of the dura, we sought to map the origin and course of meningeal nociceptors that innervate the posterior dura overlying the cerebellum. Using AAV-GFP tracing and single-unit recording techniques in male rats, we found that neurons in C2-C3 DRGs innervate the dura of the posterior fossa; that nearly half originate in DRG neurons containing CGRP and TRPV1; that nerve bundles traverse suboccipital muscles before entering the cranium through bony canals and large foramens; that central neurons receiving nociceptive information from the posterior dura are located in C2-C4 spinal cord and that their cutaneous and muscle receptive fields are found around the ears, occipital skin and neck muscles; and that administration of inflammatory mediators to their dural receptive field, sensitize their responses to stimulation of the posterior dura, peri-occipital skin and neck muscles. These findings lend rationale for the common practice of attempting to alleviate migraine headaches by targeting the greater and lesser occipital nerves with anesthetics. The findings also raise the possibility that such procedures may be more beneficial for alleviating occipital than non-occipital headaches and that occipital migraines may be associated more closely with cerebellar abnormalities than in non-occipital migraines.

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Section: Discussionmentioning

confidence: 99%

Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache

et al. 2019

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“…As a reliable and reproducible data-driven approach measuring low frequency BOLD signals, ALFF can be defined as the total power within a certain frequency range, which reflects the intensity of regional spontaneous brain activity (Zou et al, 2009, Zuo et al, 2010). The alternations in ALFF have also been observed in several disorders including chronic pain (Xue et al, 2013, Qi et al, 2015, Wang et al, 2016), amnestic mild cognitive impairment (Han et al, 2011), schizophrenia (Hoptman et al, 2010) and hepatic encephalopathy (Qi et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Acupuncture modulates the abnormal brainstem activity in migraine without aura patients

Zeng

Yin

et al. 2017

NeuroImage: Clinical

108

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Migraine is a common neurological disease with a high prevalence and unsatisfactory treatment options. The specific pathophysiological mechanisms of migraine remain unclear, which restricts the development of effective treatments for this prevalent disorder. The aims of this study were to 1) compare the spontaneous brain activity differences between Migraine without Aura (MwoA) patients and healthy controls (HCs), using amplitude of low-frequency fluctuations (ALFF) calculation method, and 2) explore how an effective treatment (verum acupuncture) could modulate the ALFF of MwoA patients. One hundred MwoA patients and forty-six matched HCs were recruited. Patients were randomized to four weeks' verum acupuncture, sham acupuncture, and waiting list groups. Patients had resting state BOLD-fMRI scan before and after treatment, while HCs only had resting state BOLD-fMRI scan at baseline. Headache intensity, headache frequency, self-rating anxiety and self-rating depression were used for clinical efficacy evaluation. Compared with HCs, MwoA patients showed increased ALFF in posterior insula and putamen/caudate, and reduced ALFF in rostral ventromedial medulla (RVM)/trigeminocervical complex (TCC). After longitudinal verum acupuncture treatment, the decreased ALFF of the RVM/TCC was normalized in migraine patients. Verum acupuncture and sham acupuncture have different modulation effects on ALFF of RVM/TCC in migraine patients. Our results suggest that impairment of the homeostasis of the trigeminovascular nociceptive pathway is involved in the neural pathophysiology of migraines. Effective treatments, such as verum acupuncture, could help to restore this imbalance.

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“…However, only the gross anatomy of the brain has been investigated in previous studies (Borsook et al, 2016; Wang et al, 2016). With a deeper understanding of migraine, the accumulated evidence has shown that the functions of different brain sub-regions vary widely, raising new demands, and challenges for future studies.…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study

Lv²,

Song³

et al. 2017

Front. Behav. Neurosci.

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Objective: The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA).Methods: Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control group) were recruited for this study. All of the subjects underwent neurological examination and magnetic resonance imaging (MRI). The MRI data were processed using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 software to obtain the FC z-score of the sub-regions of both insulas (six sub-regions on each side). Therefore, there were a total of 12 regions of interest (ROIs) that were used as seed points for the statistical analysis.Results: There was abnormal FC between the insular sub-regions and multiple brain regions in the MWoA patients compared with the healthy control group, and a clear laterality was also observed. In addition, the FC z-score of certain sub-regions was negatively correlated with the disease duration.Conclusion: Different insular sub-regions are functionally associated with different regions of the brain and therefore have different functions. In MWoA, the FC between the insular sub-regions and other brain regions was mostly reduced, while a small amount was increased; additionally, the FC may be ipsilateral with a right-side advantage. Variations in the FC of insular sub-regions can be observed as an important indicator of MWoA.

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Amplitude of low-frequency fluctuation (ALFF) and fractional ALFF in migraine patients: a resting-state functional MRI study

Cited by 81 publications

References 36 publications

Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache

Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache

Acupuncture modulates the abnormal brainstem activity in migraine without aura patients

Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study

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