How to make software analytics simpler and faster? One method is to match the complexity of analysis to the intrinsic complexity of the data being explored. For example, hyperparameter optimizers find the control settings for data miners that improve for improving the predictions generated via software analytics. Sometimes, very fast hyperparameter optimization can be achieved by just DODGE-ing away from things tried before. But when is it wise to use DODGE and when must we use more complex (and much slower) optimizers? To answer this, we applied hyperparameter optimization to 120 SE data sets that explored bad smell detection, predicting Github issue close time, bug report analysis, defect prediction, and dozens of other non-SE problems. We find that DODGE works best for data sets with low "intrinsic dimensionality" (µ D ≈ 3) and very poorly for higher-dimensional data (µ D > 8). Nearly all the SE data seen here was intrinsically low-dimensional, indicating that DODGE is applicable for many SE analytics tasks.
Photoperiod regulates the seasonal reproductive rhythms of mammals by influencing the development and function of sexual organs; however, the underlying mechanism remains unclear. We examined the morphology and functioning of the main sex organs of striped dwarf hamsters (Cricetulus barabensis) under different photoperiods (short daylight [SD], moderate daylight [MD], and long daylight [LD]) and further investigated the underlying molecular mechanisms. There was an inverse correlation between blood melatonin levels and photoperiod in the order SD > MD > LD. Decreases in body and tissue weights were observed under SD, whereas testis and epididymis weights between MD and LD were comparable. The diameters of the spermatogenic tubules, thickness of the spermatogenic epithelium, and the number of spermatogonia and Sertoli cells decreased under SD, whereas the serumluteinizing hormone, follicle-stimulating hormone, and fecal testosterone concentrations decreased under LD. In SD, bax/bcl2 protein expression increased in the testes and decreased in the epididymides, whereas LC3II/LC3I remained unchanged in the testes and increased in the epididymides compared with the MD group. In LD, bax/bcl2 and LC3II/LC3I protein expression levels were unchanged in the testes but were decreased in the epididymides. In SD and LD, adenosine triphosphate synthase and citrate synthase protein expression levels were unchanged in the testes but were decreased in the epididymides. Drp1 and Mff protein expression increased in the testes and decreased in the epididymides. Overall, different regulatory mechanisms in the testis and epididymis led to degeneration under SD and maintenance under LD, preferentially protecting mitochondrial function in the testis by regulating mitochondrial fission.
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