The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phosphorylation. And the phosphorylated protein is retained in the cytoplasm and subsequently translocates to the nucleus upon dephosphorylation, where it stimulates the expression of hundreds of genes, leading to lysosomal biogenesis and autophagy induction. The transcription factor-mediated lysosome-to-nucleus signaling can be directly controlled by several signaling molecules involved in the mTORC1, PKC, and AKT pathways. MiT/TFE family members have attracted much attention owing to their intracellular clearance of pathogenic factors in numerous diseases. Recently, multiple studies have also revealed the MiT/TFE proteins as master regulators of cellular metabolic reprogramming, converging on autophagic and lysosomal function and playing a critical role in cancer, suggesting that novel therapeutic strategies could be based on the modulation of MiT/TFE family member activity. Here, we present an overview of the latest research on MiT/TFE transcriptional factors and their potential mechanisms in cancer.
The purpose of this study was to investigate the status of occupational stress and its influence on the quality of life of copper-nickel miners, in order to provide a theoretical basis for alleviating occupational stress to improve their quality of life. Stratified cluster sampling and a self-administered questionnaire survey were used. The Effort–Reward Imbalance (ERI) questionnaire and the SF-36 (36-Item Short Form) health survey scale were administered to all 2000 miners registered with a copper-nickel mining human resources department and who had been on duty for more than one year. In total, 1857 valid questionnaires were collected, with a response rate of 92.85%. The percentage of the copper-nickel miners suffering from occupational stress was 42.65%. A statistically significant difference was observed in relation to the prevalence of occupational stress among miners of different genders, ages, education levels, and operating units. The occupational stress detection rate was higher for males than females. Miners aged between 30 and 34 years exhibited the highest level of occupational stress compared to other age groups. Those with a junior college education exhibited the highest rate of occupational stress compared to those with other levels of education. Those working in the smelting unit exhibited the highest rate of occupational stress compared to those working in other operational units. Those classified as experiencing stress (an ERI score >1) had lower quality of life scores than miners classified as not experiencing stress (an ERI score ≤1). The results show that level of education, monthly income, and degree of occupational stress affect quality of life among copper-nickel miners. It was found that older age, lower income, higher education level, and higher degree of occupational stress were factors related to poorer quality of life. Copper-nickel miners have high levels of occupational stress, and occupational stress is a risk factor that can diminish quality of life.
ObjectiveStrategies and measures for fighting occupational stress in China are inadequate. This study aimed to determine the level of occupational stress in coal miners and to assess the associations between occupational stress and job burn-out, depression and hypertension. The results could provide clues for preventive measures and strategies to improve the psychological well-being of this population.DesignCross-sectional study.SettingXinjiang Coal Administration Bureau.ParticipantsFour coal mines were selected randomly (computer-generated random number-based selection process) from the 21 coal mines of Xinjiang, and all miners with >1 year of employment were screened for participation.Primary and secondary outcome measuresA general demographic questionnaire, the Self-rating Depression Scale, the Effort–Reward Imbalance (ERI) model and the Maslach Burn-out Inventory.ResultsA total of 1400 questionnaires were collected, including 1334 (95.3%) valid questionnaires. This survey indicated that 1107 (83.0%) participants with an ERI score >1 (high occupational stress) and 227 (12.8%) had ERI ≤1. Severe depression was found in 21.7% of the participants. Job burn-out was positively correlated with occupational stress, which was, in turn, associated with depression. Multivariable linear regression analysis showed that depression (β=0.006, p=0.012), sex (β=0.358, p<0.001) and occupational stress (β=0.702, p<0.001) were independently associated with job burn-out. Working years (β=−0.086, p=0.015) and job burn-out (β=0.022, p<0.001) were directly associated with depression.ConclusionThis study highlights that occupational stress may affect job burn-out, depression symptoms and hypertension. A higher degree of occupational stress was associated with poorer mental status and hypertension.
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