Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia

Abliz, Ablat; Aji, Qimangul; Abdusalam, Elzira; Sun, Xuemei; Abdurahman, Adil; Zhou, Wenting; Moore, Nicholas; Umar, Asad

doi:10.1016/j.jep.2013.12.010

Cited by 59 publications

(35 citation statements)

References 7 publications

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“…Hyperlipidemia comprises a group of plasma lipoprotein abnormalities, including increased triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL), and reduced high density lipoprotein cholesterol (HDL) concentrations (Chen et al, 2014b). Hyperlipidemia is a dominant risk factor that contributes to cardiovascular disease (Abliz et al, 2014; Kim et al, 2015), and its development has become a difficult public health problem (Chen et al, 2014b). At present, drug therapy is the preferred treatment for hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet

Sun

et al. 2017

Front. Microbiol.

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Multiple lines of evidence suggest that the gut microbiota plays vital roles in metabolic diseases such as hyperlipidemia. Previous studies have confirmed that krill oil can alleviate hyperlipidemia, but the underlying mechanism remains unclear. To discern whether krill oil changes the structure of the gut microbiota during the hyperlipidemia treatment, 72 mice were acclimatized with a standard chow diet for 2 weeks and then randomly allocated to receive a standard chow diet (control group, n = 12) or a high-sugar-high-fat (HSHF) diet supplemented with a low (100 μg/g·d, HSHF+LD group, n = 12), moderate (200 μg/g·d, HSHF+MD group, n = 12) or high dosage of krill oil (600 μg/g·d, HSHF+HD group, n = 12), simvastatin (HSHF+S group, n = 12) or saline (HSHF group, n = 12) continuously for 12 weeks. The resulting weight gains were attenuated, the liver index and the low-density lipoprotein, total cholesterol and triglyceride concentrations showed a stepwise reduction in the treated groups compared with those of the control group. A dose-dependent modulation of the gut microbiota was observed after treatment with krill oil. Low- and moderate- doses of krill oil increased the similarity between the composition of the HSHF diet-induced gut microbiota and that of the control, whereas the mice fed the high-dose exhibited a unique gut microbiota structure that was different from that of the control and HSHF groups. Sixty-five key operational taxonomic units (OTUs) that responded to the krill oil treatment were identified using redundancy analysis, of which 26 OTUs were increased and 39 OTUs were decreased compared with those of the HSHF group. In conclusion, the results obtained in this study suggest that the structural alterations in the gut microbiota induced by krill oil treatment were dose-dependent and associated with the alleviation of hyperlipidemia. Additionally, the high-dose krill oil treatment showed combined effects on the alleviation of hyperlipidemia and obesity.

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Section: Introductionmentioning

confidence: 99%

Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet

Sun

et al. 2017

Front. Microbiol.

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“…Our results suggested that the model groups markedly increased MDA and TG levels (Figure ). However, supplementation of LMP or Lentinan can decrease the MDA and TG levels (Abliz et al, ). As seen in Figure a,b, group P3 (LMP, 200 mg/kg) asserted the same effects as compared with the group P (Lentinan, 100 mg/kg).…”

Section: Resultsmentioning

confidence: 99%

Optimization of Maca polysaccharide extraction process and its chemo‐protective effects on cyclophosphamide‐induced mice

Wang

Huang

et al. 2018

J Food Process Engineering

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In this study, the extraction process of Maca polysaccharide (LMP) was deeply studied and its chemo‐protective effects on Cyclophosphamide (Cy)‐induced mice were evaluated. By single factor investigation and response surface methodology optimization, it was found that the liquid‐to‐solid ratio, extraction time, and extraction temperature were the main factors which affected the extraction yield of LMP. The optimum extraction process was obtained by Box–Behnken design combined with response surface methodology. It was found that, at the condition of liquid‐to‐solid ratio of 30:1; extraction time of 2.3 hr; and extraction temperature of 90°C, the yield of the LMP could reach 46.56%. Furthermore, by oral administration of LMP, the cyclophosphamide‐induced mice showed the proliferation of lymphocyte and the phagocytic capacity of macrophages’ enhancements. The number of white blood cell, red blood cell, and platelets in the peripheral blood were up‐regulated; the spleen total superoxide dismutase, Catalase, and Glutathione‐peroxidase activities were enhanced, while the Serum malondialdehyde and Triacylglycerols content was reduced. Therefore, our work provided an effective way for extraction of LMP and demonstrated the chemo‐protective effects of LMP on the animal level. Practical application Natural polysaccharides from functional food sources are widely accepted for their bioactive activities. As extraction conditions significantly affected the quality and yield of polysaccharides, the effective extraction process for polysaccharides should be systematically investigated. In the current work, the optimum conditions for polysaccharides extraction from Maca (Lepidium meyenii Walp.) (LMP) were obtained using liquid‐to‐solid ratio of 30:1 for 2.3 hr at 90°C. The Mass characterization and Monosaccharide Composition of LMP were also determined. Furthermore, the extracted LMP exhibited well Chemo‐protective activities on Cyclophosphamide‐induced mice. Therefore, our work showed the potential applications of Maca polysaccharides as the easily accessible source of natural immunopotentiating agents in function food and pharmaceutical industry.

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“…COM dosedependently reduced TC, TG, LDL-C and MDA, inhibited the activity of ALT, AST and LPS, increased HDL-C content, increased the activity of SOD, GSH-PX, LPL and HL, and reduced liver steatosis in hyperlipidaemia rats, significant at medium and high doses. The effect of COM was similar to that of simvastatin except for increased lipoprotein lipase and hepatic lipase which were reduced by COM but not by simvastatin [146]. The effects of Cydonia oblonga Miller (COM) total flavonoids (TF) from leaves and fruit on the blood lipid and antioxidant potentials were studied using hyperlipidaemic rat models.…”

Section: Cydonia Oblongamentioning

confidence: 95%

Medicinal plants with cardiovascular effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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Abstract:-Previous researches revealed that many medicinal plants affected cardiovascular function and can be utilize for therapeutic purposes. This review will highlight the cardiac, cardioprotective, vascular, hypolipidemic, fibrinolytic and anti platelet aggregating of medicinal plants as a second part of our previous review.Keywords : medicinal plants, herbs, cardiac, cardioprotective, vascular, hypolipidemic, [30]. This review was designed to cover the cardiac, cardioprotective, vascular, hypolipidemic, fibrinolytic and anti platelet aggregating of medicinal plants as a second part of our previous review.

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Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia

Cited by 59 publications

References 7 publications

Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet

Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet

Optimization of Maca polysaccharide extraction process and its chemo‐protective effects on cyclophosphamide‐induced mice

Medicinal plants with cardiovascular effects (part 2): plant based review

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