Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

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(2016). Experimentation and numerical modeling of cyclic voltammetry for electrochemical micro-sized sensors under the influence of electrolyte flow. Journal of Electroanalytical Chemistry, 763(February), 141-148. DOI: 10.1016141-148. DOI: 10. /j.jelechem.2015 exchange current density leads to a shift in the peak current of the recorded CV.Finally, the results also demonstrate that the working electrode at the center of the fluidic cell records accurate measurement than placing the electrode at the bottom of the cell. The numerical results and the experimental data show both qualitative and quantitative good agreement.