SummaryOur study aimed to clarify the correlation between miR‐1247‐5p expression and clinicopathological parameters and survival of patients with breast cancer (BC). We evaluated the expression level of miR‐1247‐5p in 224 formalin‐fixed, paraffin‐embedded specimens (112 BC and matched cancer free tissues) by quantitative real‐time reverse transcriptase polymerase chain reaction (qRT‐PCR). miR‐1247‐5p expression in BC tissues was found to be decreased compared with matched normal tissues (P < 0.01). Additionally, low miR‐1247‐5p expression in BC tissues was significantly associated with the advanced TNM stage (P = 0.007), lymph node metastasis (P = 0.015), poorer pathological differentiation (P = 0.005) and molecular subtype (P = 0.027). The patients in the low miR‐1247‐5p group had a shorter disease‐free survival and overall survival than those in the high miR‐1247‐5p group (P < 0.01). Furthermore, the univariate and the multivariate analyses showed that miR‐1247‐5p expression was an independent predictor of overall survival (P < 0.01). Our study showed that miR‐1247‐5p was related to the biological behaviour of breast tumour and prognosis of patients with BC. miR‐1247‐5p could be a novel tumour suppressor and act as a potential biomarker and therapeutic agent for breast carcinoma.
Background Totally implantable venous access port (TIVAP) has become an effective approach for venous access chemotherapy in cancer treatment. We aimed to show the important procedures of clinical application of TIVAP and complications management in breast cancer.Patients and Methods From January 2013 to December 2017, patients with breast cancer who took TIVAP operation were investigated. The key procedures of TIVAP conduct and its complications were evaluated in this study.Results One hundred and ten ports were applied to 110 patients with breast cancer. All ports were successfully implanted in all patients including 108 male and 2 male patients. Patients were followed for an average of 275 days. Conclusion It is safe and effective of TIVAP implantation by blind puncture applied in patients with breast cancer. Chemotherapeutic drugs delivery on the placement day seems safe and showed no more complications.
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