Highlights d 3q26 CNG and TP53 mutation associate with progression of carcinoma in situ to LSCC d PRKCI, SOX2, and ECT2 overexpression transforms Trp53 À/À mouse lung basal stem cells d Active PKCi-SOX2 and PKCi-ECT2 signaling is required for LBSC transformation d A PKCi-SOX2 molecular signature suggests unique therapeutic vulnerabilities in LSCC

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The designed synthesis of nanotwin architectures and thus-induced phase junctions expresses huge significance for semiconductor photocatalysts. However, current methods of producing nanotwins mainly involve high-temperature thermal treatment and tedious reaction steps, generally resulting in large bulk structure with ill-defined morphology and low specific surface area. Here, we propose a mild ligand-assisted coordinative self-assembly method to synthesize uniform mesoporous Zn x Cd 1−x S nanospheres with ultrahigh surface areas (148−312 m 2 g −1 ) and controllable diameter (90−370 nm). Moreover, the sample possesses abundant phase junctions induced by nanotwins containing both hexagonal and cubic segments. With the synergy of the twininduced phase junctions and high surface area, the as-prepared mesoporous Zn 0.82 Cd 0.18 S nanospheres exhibit a remarkable photocatalytic H 2 evolution rate of 13.46 mmol h −1 g −1 with free noble metal. The mechanism of photocarrier dynamics was studied by transient photovoltage spectroscopy, manifesting that the photocarrier lifetime of Zn 0.82 Cd 0.18 S is largely prolonged and therefore improves the charge separation efficiency and photocatalytic activity.

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BackgroundAlexithymia is characterised by difficulties identifying and describing emotions. Few studies have investigated how alexithymia influences decision-making under different conditions (ambiguity and risk). This study aimed to examine whether alexithymia contributes to impairment in decision-making.MethodThis study included 42 participants with high scores in the Chinese version of Toronto Alexithymia Scale (alexithymia group), and 44 matched subjects with low scores (control group). Decision-making was measured using the Iowa Gambling Task (IGT) and the Game of Dice Task (GDT).ResultsThe main findings of this study revealed selective deficits in IGT performance for the alexithymia group, while GDT performance was unimpaired when compared with the control group. In IGT, total netscores were lower for the alexithymia group compared to the control group, particularly with regard to block 5. Moreover, the alexithymia individuals selected significantly more adverse cards than the controls, indicating significant decision-making impairments.ConclusionAlexithymia selectively influences decision-making under ambiguity.

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