In our preview research, four novel quaternary ammonium hybrids were isolated from the Stereum hirsutum FP-91666. To further discover this type compounds, S. hirsutum was fermented in 30 L YMG broth, and eight hybrid compounds including four new quaternary ammoniums were obtained, which are sesquiterpenes combined with α-amino acids.Their structures were elucidated by extensive spectroscopic analyses, including 1D-and 2D-NMR, and HR-MS experiments.
Fungi are one of the important sources of active compounds. However, in fungi, most of the secondary metabolic biosynthetic gene clusters are weakly expressed or silenced under conventional culture conditions.
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