Antibacterial diketopiperazines from an endophytic fungus Bionectria sp. Y1085

Yang, Yin‐He; Yang, Da‐Song; Li, Guohong; Pu, Xue-Juan; Mo, Ming-He; Zhao, Pei‐Ji

doi:10.1038/s41429-019-0209-5

Cited by 22 publications

(26 citation statements)

References 28 publications

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“…F-4908 - [12] Immunosuppressive and antifungal activities [13] IB-01212 (14) Clonostachys sp. ESNA-A009 Cytotoxic activity [14] Antileishmanial activity [15] Pullularin A (15) Bionectria ochroleuca Cytotoxic activity [4] Pullularin C (16) Bionectria ochroleuca Cytotoxic activity [4] Pullularin E (17) Bionectria ochroleuca - [4] Piperazines Bionectin A (18) Bionectria byssicola F120 Antibacterial activity [16] Bionectin B (19) Bionectria byssicola F120 Antibacterial activity [16] Bionectin C (20) Bionectria byssicola F120 - [16] Bionectin D (21) Bionectria sp. Y1085 Antibacterial activity [17] Bionectin E (22) Bionectria sp.…”

Section: Linear Oligopeptidesmentioning

confidence: 99%

“…ESNA-A009 Cytotoxic activity [14] Antileishmanial activity [15] Pullularin A (15) Bionectria ochroleuca Cytotoxic activity [4] Pullularin C (16) Bionectria ochroleuca Cytotoxic activity [4] Pullularin E (17) Bionectria ochroleuca - [4] Piperazines Bionectin A (18) Bionectria byssicola F120 Antibacterial activity [16] Bionectin B (19) Bionectria byssicola F120 Antibacterial activity [16] Bionectin C (20) Bionectria byssicola F120 - [16] Bionectin D (21) Bionectria sp. Y1085 Antibacterial activity [17] Bionectin E (22) Bionectria sp. Y1085 Antibacterial activity [17] 3,6-Bis(methylthio)-cyclo(a lanyltryptophyl) (23) Nectria inventa Trypanocidal activity [18] Chaetocin (24) Nectria inventa Trypanocidal activity [18] Chetoseminudin B (25) Nectria inventa Trypanocidal activity [18] Clonocoprogen A (26) Clonostachys compactiuscula…”

Section: Linear Oligopeptidesmentioning

confidence: 99%

“…Y1085 Antibacterial activity [17] Bionectin E (22) Bionectria sp. Y1085 Antibacterial activity [17] 3,6-Bis(methylthio)-cyclo(a lanyltryptophyl) (23) Nectria inventa Trypanocidal activity [18] Chaetocin (24) Nectria inventa Trypanocidal activity [18] Chetoseminudin B (25) Nectria inventa Trypanocidal activity [18] Clonocoprogen A (26) Clonostachys compactiuscula…”

Section: Linear Oligopeptidesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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Clonostachys (teleomorph: Bionectria) fungi are well known to produce a variety of secondary metabolites with various biological activities to show their pharmaceutical and agrochemical applications. Up to now, at least 229 secondary metabolites, mainly including 84 nitrogen-containing metabolites, 85 polyketides, 40 terpenoids, and 20 other metabolites, have been reported. Many of these compounds exhibit biological activities, such as cytotoxic, antimicrobial, antileishmanial, antimalarial activities. This mini-review aims to summarize the diversity of the secondary metabolites as well as their occurrences in Clonostachys fungi and biological activities.

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Section: Linear Oligopeptidesmentioning

confidence: 99%

Section: Linear Oligopeptidesmentioning

confidence: 99%

Section: Linear Oligopeptidesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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“…A group of structurally and actively diverse metabolites were produced by plant pathogenic strains [3][4][5], which are responsible for function as essential determinants of pathogenicity or virulence. The rice blast fungus Magnaporthe grisea (imperfect stage of Pyricularia grisea Sacc.)…”

Section: Introductionmentioning

confidence: 99%

“…Some secondary metabolites (such as melanin, siderophores and fumonisin) of pathogenic fungi often function as essential determinants of pathogenicity and are involved in the infection process [10,11]. Thus, examining their secondary metabolism leads to the discovery of novel compounds with interesting structures or modes of action that could be useful for agrochemistry or pharmacology [5]. In the work, chemical investigations of a strain M. grisea M639 have led to the discovery of four new aromatic polyketides griseaketides A-D (1-4), as well as 15 known compounds (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Griseaketides A–D, New Aromatic Polyketides from the Pathogenic Fungus Magnaporthe grisea

Yang

Lei

et al. 2019

Molecules

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Magnaporthe grisea is the causal agent of rice blast disease, which is the most serious disease of cultivated rice. Aromatic polyketides are its typical metabolites and are involved in the infection process. In the search for novel lead compounds, chemical investigation of the fungus M. grisea M639 has led to the isolation of four new aromatic polyketides (salicylaldehyde skeleton bearing an unsaturated side chain), griseaketides A–D (1–4), as well as 15 known compounds (5–19). The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses, including HR-MS, 2D NMR. Compound 12 showed prominent activity that killed 94.5% of C. elegans at 400 ppm and 66.9% at 200 ppm over 24 h. This is the first report describing the nematicidal activity of this type aromatic polyketide.

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