This paper uses a bibliometric analysis method to probe into the evolution of China's science and technology policies from 1949 to 2010, and the roles of core government agencies in policy-making. We obtained 4,707 Chinese S&T policies from GDIS, a Chinese public policy database provided by Tsinghua University. Co-word analysis and network analysis were applied in mapping the topics of S&T policies and collaboration among the agencies, while citation analysis was applied to assess the influence of S&T policies. Findings include: first, the focus of Chinese S&T policies is mainly on applied research and industrialization, rather than basic research; second, more and more government agencies are involved in making S&T policies, but collaboration efforts are not significantly increasing; last but not least, the influence of different S&T policies is determined by the administrative ranking of the policy-making agencies responsible for drafting those policies.
This article presents a comprehensive review of China's policy system for the management of natural hazard-induced disasters from 1949 to 2016 through a quantitative bibliometric analysis of 5472 policy documents on such disasters. It identifies four phases of China's evolving disaster management system, which focused on agriculture, economic development, government and professional capacity building, and disaster governance, respectively. Characteristics of policies and contributing factors of policy change in each of the four phases are discussed in depth. This article provides a quantitative foundation for understanding the dynamic policy change of the disaster management system in China with a particular emphasis on the governance capacity and may serve as a basis for exploring the potential pathways of transformation according to the Sendai Framework for Disaster Risk Reduction 2015-2030 and the Sustainable Development Goals.
Tumor cells with heterogeneity and diversity can express different markers. At present, positive separation of circulating tumor cells (CTC) taking EpCAM as the marker was used in most cases which could be one-sided, while this study successfully prepared four antibody-modified magnetic immunoliposomes (MIL) by using the self-assembled liposome with antibody derivatives. This study aims to explore the separation efficiency and clinical detection feasibility of single or combined use of MIL with multi-tumor markers on different tumors. Captured CTC were stained with CK-FITC, CD45-PE and DAPI, and fluorescence microscope was used for the observation, analysis and calculation. The result indicated that the CTC number positive rate in blood samples of four different magnetic balls on the same patient could be up to 87.5% in 32 patients with 14 different kinds tumors. While the effect of directly mixed separation by four kinds of magnetic balls was not satisfying. It suggested that the MIL of multi-tumor markers could be a powerful tool for CTC separation in application of tumor screening and prognosis.
Nanotechnology is considered to be a key technology that has an important influence on the emergence and development of a series of high-technologies in the 21st century. Due to its multidisciplinary nature, nanotechnology requires extensive multi-sector collaborations to foster more efficient development outcomes. This paper proposed a novel triple helix model to analyse the globalization of China’s nanotechnology innovation. This analytical framework will include three main aspects: first, the independent and interactive relationship among universities, governments, and industries; second, the vertical progress of globalization; and third, some influential innovative elements throughout the process. Afterwards, we demonstrate the model via a case study on the China International Nanotech Innovation Cluster. Finally, the paper summarizes the propelling roles and active impact three main entities played in the nanotechnology globalization process, as well as the trend and challenge of globalization. Findings offer helpful implications for the triple helix innovation in other industries.
Background Forkhead box protein M1 (FOXM1) is an oncogene regulating tumor growth and metastasis. Exosome was suggested to mediate cell communication by delivering active molecules in cancers. However, the existence of FOXM1 in circulating exosomes and the role of exosome FOXM1 in gastric cancer (GC) were not clear. This study aims to investigate the potential role of FOXM1 related long noncoding RNA (FRLnc1) in exosomes in GC. Results The prepared CD63 immunomagnetic beads (CD63-IMB) had the characteristics of good dispersity and high magnetic response. The isolated exosomes were presented with elliptical membranous particles under a transmission electron microscope (TEM), with the particle size of 89.78 ± 4.8 nm. Western blot (WB) results showed that the exosomes were rich in CD9 and CD81. The Dil-labeled exosomes were distributed around cytoplasm and nucleus of cells by imaging flow cytometry (IFC) analysis. The results of quantitative real-time PCR (qRT-PCR) revealed that the FRLnc1 expressions were up-regulated in GC cells, tumor tissues, and serum of GC patients. An obviously up-regulated FRLnc1 expression was found in serum exosomes of GC patients. Up-regulation of FRLnc1 expression was closely correlated to lymph node metastasis (LNM) and TNM stage with the combination of relevant clinicopathological parameter analysis. The in vitro functional analyses demonstrated that FRLnc1 knockdown by RNA interference suppressed cell proliferation and migration in HGC-27 cells, whereas FRLnc1 overexpression promoted cell proliferation and migration in MKN45 cells. After exosome treatment, the FRLnc1 expression was significantly increased in MKN45 cells, and the MKN45 cells showed increased ability of proliferation and migration. Conclusion GC cells-derived exosomes played roles in promoting the growth and metastasis of GC by transporting FRLnc1, suggesting that FRLnc1 in the exosomes may be a potential biomarker for the diagnosis and treatment of GC. The delivery of FRLnc1 by the exosomes may provide a new way for the treatment of GC. Trial registration 2020-KYSB-094. Registered 23 March 2020—Retrospectively registered Graphic abstract
Abstract:Influenza virus vaccine plays an important role in preventing influenza and protecting people's health. The international collaboration in influenza virus vaccine field is related to the sustainability of healthcare. To understand the elaborate characteristics of multiform international collaboration in the influenza virus vaccine field, this paper constructs a multilayered analytical framework (at the country, city and institution levels) of international scientific collaboration to examine the regional distribution, dynamic changes and common themes of collaboration. A total of 1878 international collaboration papers of the influenza virus vaccine field published from 2006 to 2013 were collected from the Web of Science database. Based on this dataset, the paper utilizes bibliometrics and social network analysis approaches to explore international publication trends and collaboration performance in the influenza virus vaccine field. Results show that: (1) the three kinds of collaboration networks (country, city and institution levels) all present dynamic structures, strong core-periphery characteristics, and their degree centrality distributions follows segmented Zifp-Pareto distribution; and (2) although it is known that there exist corresponding relationships among countries, cities and institutions in the geographical position, most of their associated categories, network locations and changing trends are all non-conformal. These findings suggest that multilayered analysis enables a more comprehensive understanding of international scientific collaboration in the influenza virus vaccine field. In general, detailed conclusions can help different levels of governments to draw policy implications for promoting further international collaboration research to enhance the ability on preventing the disease.
Sustainable development of mega-projects has drawn many concerns around the world. The theory of disruptive innovation in mega-projects is a typical sustainable development pattern but still lacks systematic understanding. This article takes China's high-speed rail (CHSR) project as an example to analyze the disruptive innovation pattern of mega-projects. First, this paper systematically traces the theories of disruptive innovation and summarizes the connotations of disruptive innovation. Simultaneously, from the historical development of several typical mega-projects in China, this paper summarizes the connotations of mega-projects. Based on two connotations, this paper summarizes the theoretical basis of disruptive innovation in mega-projects. Second, this paper takes the CHSR project as a case to analyze its innovation pattern from the analysis of the development process, operation mechanism and influence in sustainability; the disruptive innovation pattern is put forward afterward. Third, the discussion is drawn from the perspectives of the characteristics, scope of application and innovation environment of the disruptive innovation of CHSR. Last, the conclusions of this article are summarized.
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