Lithium niobate (LN) devices have been widely used in optical communication and nonlinear optics due to its attractive optical properties. The emergence of thin-film lithium niobate on insulator (LNOI) improves performances of LN-based devices greatly. However, a high-efficient fiber-chip optical coupler is still necessary for the LNOI-based devices for practical applications. In this paper, we demonstrate a highly efficient and polarizationindependent edge coupler based on LNOI. The coupler, fabricated by standard semiconductor process, shows a low fiber-chip coupling loss of 0.54 dB/0.59 dB per facet at 1550 nm for TE/TM light respectively, when coupled with ultra-high numerical aperture fiber (UHNAF) of which mode field diameter is about 3.2 μm. The coupling loss is lower than 1dB/facet for both TE and TM light at wavelengths longer than 1527nm. A relatively large tolerance for optical misalignment is also proved. The coupler shows a promising stability in high optical power and temperature variation.
Photoacoustic imaging relies on diffused photons for optical contrast and diffracted ultrasound for high resolution. As a tomographic imaging modality, often an inverse problem of acoustic diffraction needs to be solved to reconstruct a photoacoustic image. The inverse problem is complicated by the fact that the acoustic properties, including the speed of sound distribution, in the image field of view are unknown. During reconstruction, subtle changes of the speed of sound in the acoustic ray path may accumulate and give rise to noticeable blurring in the image. Thus, in addition to the ultrasound detection bandwidth, inaccurate acoustic modeling, especially the unawareness of the speed of sound, defines the image resolution and influences image quantification. Here, we proposed a method termed feature coupling to jointly reconstruct the speed of sound distribution and a photoacoustic image with improved sharpness, at no additional hardware cost. Simulations, phantom studies, and in vivo experiments demonstrated the effectiveness and reliability of our method.
Photoacoustic (PA) imaging provides morphological and functional information about angiogenesis and thus is potentially suitable for breast cancer diagnosis. However, the development of PA breast imaging has been hindered by inadequate patients and a lack of ground truth images. Here, we report a digital breast phantom with realistic acoustic and optical properties, with which a digital PA-ultrasound imaging pipeline is developed to create a diverse pool of virtual patients with three types of masses: ductal carcinoma in situ, invasive breast cancer, and fibroadenoma. The experimental results demonstrate that our model is realistic, flexible, and can be potentially useful for accelerating the development of PA breast imaging technology.
For many optical imaging modalities, image qualities are inevitably degraded by wavefront distortions caused by varying light speed. In optical microscopy and astronomy, adaptive optics (AO) has long been applied to compensate for such unwanted aberrations. Photoacoustic computed tomography (PACT), despite relying on the ultrasonic wave for image formation, suffers from the acoustic version of the same problem. However, this problem has traditionally been regarded as an inverse problem of jointly reconstructing both the initial pressure and the sound speed distributions. In this work, we proposed a method similar to indirect wavefront sensing in AO. We argued that wavefront distortions can be extracted and corrected by a frequency domain analysis of local images. In addition to an adaptively reconstructed aberration-free image, the speed of sound map can be subsequently estimated. We demonstrated the method by
in silico
, phantom, and
in vivo
experiments.
Recently, thin-film lithium niobate coherent modulators have emerged as a promising candidate for the next generation coherent communication system. High performance polarization splitter-rotators (PSRs) are essential to further achieve dual polarization coherent modulators. Here we present a PSR on the lithium niobate on insulator (LNOI) platform with the measured insertion loss less than 1 dB, extinction ratio exceeding 26.6 dB and 19.6 dB for TE0 and TM0 modes, working bandwidth of 1520–1580 nm and total length of 440 µm. In addition, a relatively large fabrication tolerance for waveguide width is also proved. This demonstrated PSR can find its potential application in polarization-division multiplexing (PDM) optical transmitter based on LNOI.
Ultrasound and photoacoustic imaging are emerging as powerful tools to study brain structures and functions. The skull introduces significant distortion and attenuation of the ultrasound signals deteriorating image quality. For biological studies employing rodents, craniotomy is often times performed to enhance image qualities. However, craniotomy is unsuitable for longitudinal studies, where a long-term cranial window is needed to prevent repeated surgeries. Here, we propose a mouse model to eliminate sound blockage by the top portion of the skull, while minimum physiological perturbation to the imaged object is incurred. With the new mouse model, no craniotomy is needed before each imaging experiment. The effectiveness of our method was confirmed by three imaging systems: photoacoustic computed tomography, ultrasound imaging, and photoacoustic mesoscopy. Functional photoacoustic imaging of the mouse brain hemodynamics was also conducted. We expect new applications to be enabled by the new mouse model for photoacoustic and ultrasound imaging.
For photoacoustic computed tomography (PACT), an insufficient number of ultrasound detectors can cause serious streak-type artifacts. These artifacts get overlaid on top of image features, and thus locally jeopardize image quality and resolution. Here, a reconstruction algorithm, termed Contamination-Tracing Back-Projection (CTBP), is proposed for the mitigation of streak-type artifacts. During reconstruction, CTBP adaptively adjusts the back-projection weight, whose value is determined by the likelihood of contamination, to minimize the negative influences of strong absorbers. An iterative solution of the eikonal equation is implemented to accurately trace the time of flight of different pixels. Numerical, phantom and in vivo experiments demonstrate that CTBP can dramatically suppress streak artifacts in PACT and improve image quality.
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