The detailed spatial distributions and diurnal variations of low-level jets (LLJs) during early summer (May–July) in China are documented using 2006–11 hourly model data from the Weather Research and Forecasting (WRF) Model with a 9-km horizontal resolution. It was found that LLJs frequently occur in the following regions of China: the Tarim basin, northeastern China, the Tibetan Plateau (TP), and southern China. The LLJs over China are classified into two types: boundary layer jets (BLJs, below 1 km) and synoptic-system-related LLJs (SLLJs, within 1–4 km). The LLJs in the Tarim basin and the TP are mainly BLJs. The SLLJs over southern China and northeastern China are associated with the mei-yu front and northeast cold vortex (NECV), respectively. The BLJs in all regions show pronounced diurnal variations with maximum occurrences at nighttime or in the early morning, whereas diurnal variations of SLLJs vary, depending on the location. From the analysis of model data, the diurnal variation of BLJs is mainly caused by inertial oscillation at nighttime and vertical mixing in the boundary layer during daytime. Over northeastern China, SLLJ occurrences show little diurnal variation. Over southern China, two diurnal modes of SLLJs, propagation and stationary, exist and have seasonal variations, which is generally consistent with diurnal variations of precipitation.

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The non-receptor tyrosine kinase SRC is a key mediator of cellular protumorigenic signals. SRC is aberrantly over-expressed and activated in more than 80% of colorectal cancer (CRC) patients, therefore regulation of its stability and activity is essential. Here, we report a significant down regulation of SNX10 (sorting nexin 10) in human CRC tissues, which is closely related to tumor differentiation, TNM stage, lymph node metastasis and survival period. SNX10 deficiency in normal and neoplastic colorectal epithelial cells promotes initiation and progression of CRC in mice. SNX10 controls SRC levels by mediating autophagosome-lysosome fusion and SRC recruitment for autophagic degradation. These mechanisms ensure proper controlling of the activities of SRC-STAT3 and SRC-CTNNB1 signaling pathways by up-regulating SNX10 expression under stress conditions. These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development.

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Allicin is the major biologically active compounds of freshly crushed garlic. It has been reported to inhibit the proliferation and promote the apoptosis of multiple colorectal cancer cells. However, the anti-colorectal cancer effect of Allicin has not been verified by in vivo studies. In the present study, we investigated the effect of Allicin on azoxymethane/dextran sodium sulfate (AOM/DSS) colorectal cancer mouse model and explore the underlying possible mechanism. Our result showed that Allicin could inhibit colonic tumorigenesis of AOM/DSS mice in vivo. In vitro study showed that Allicin promoted the apoptosis and suppressed the survival and proliferation of HCT116 cells. The molecular mechanism is related to the suppression of STAT3 signaling activation. Thus, our data provide further support for Allicin as a potential favorable supplement for human colorectal cancer.

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