α-Keton sulfides are versatile building blocks
in organic
synthesis. From thioic acids and alkenes, we were able to develop
the direct synthesis of α-keton thiol esters via photocatalytic
oxidative radical additions. This reaction well matches the idea of
green chemistry. It takes the advantage of thioxanthone as an inexpensive
organic photocatalyst, O2 as a green oxidant, EtOAc as
a green solvent, and visible light as a sustainable energy source,
and the only byproduct is water.
To observe the effects of Fu's subcutaneous needling (FSN) and acupuncture treatment on the mitochondrial structure and function of the skeletal muscle tissue of rats with sciatica. Forty Sprague–Dawley rats were divided into control, model, acupuncture, and FSN groups (10 each) according to a random number table. The control group was left untreated. Rats in the FSN group were treated with FSN once every 2 days for three times, respectively (days 1, 3, 5, and 7), to cooperate with reperfusion approach. The acupuncture group was treated at the same timeline as that of the FSN group. Changes in the mechanical pain threshold, mitochondrial ultrastructure, mitochondrial citrate synthase (CS) activities, mitochondrial respiratory chain complex II, and mitochondrial COX- I protein expression in the skeletal muscle of rats treated with different treatments were compared with those of the model group. The pain thresholds of the rats were remarkably higher after FSN treatment and acupuncture, and the pain threshold of the FSN group was higher than that of the acupuncture group. Compared with the control group, the mitochondria of the model group had a damaged ultrastructure, were arranged in a disorganized manner, accumulated under the basement membrane, and appeared vacuolated with autophagosomes. The state of mitochondria in the FSN group was close to that in the control group and was remarkably better than that in the acupuncture group. The activities of mitochondrial CS and respiratory chain complex II in the skeletal muscle of the treated rats decreased compared with the control group (P<0.05), and their levels were better in the FSN group than in the acupuncture group (P<0.05). FSN treatment for 1 week considerably improved the pain thresholds and improved the skeletal muscle mitochondrial ultrastructure and mitochondrial function in rats with sciatica.
The arrival time of a microseismic event is an important piece of information for microseismic monitoring. The accuracy and efficiency of arrival time identification is affected by many factors, such as the low signal-to-noise ratio (SNR) of the records, the vast amount of real-time monitoring records, and the abnormal situations of monitoring equipment. In order to eliminate the interference of these factors, we propose a method based on phase-only correlation (POC) to estimate the relative arrival times of microseismic events. The proposed method includes three main steps:(1) The SNR of the records is improved via time-frequency transform, which is used to obtain the time-frequency representation of each trace of a microseismic event.(2) The POC functions of all pairs of time-frequency representations are calculated. The peak value of the POC function indicates the similarity of the traces, and the peak position in the time lag axis indicates the relative arrival times between the traces. (3) Using the peak values as weighting coefficients of the linear equations, consistency processing is used to exclude any abnormal situations and obtain the optimal relative arrival times. We used synthetic data and field data to validate the proposed method. Comparing with Akaike information criterion (AIC) and cross-correlation, the proposed method is more robust at estimating the relative arrival time and excluding the influence of abnormal situations.
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