Chlorogenic acid
(CGA), a phenolic acid from coffee, has been regarded
as a powerful ingredient against oxidative stress and inflammation.
Meanwhile, its healing feature to interfere with periodontal disease
(PD) makes it a promising drug candidate. However, the existing methods
for chlorogenic acid detection limit its practical application in
purification and further pharmacological study in stomatology due
to their lack of accuracy and productivity. Therefore, it is crucial
to find a forceful approach to precisely evaluate CGA for an in-depth
anti-PD study. In this work, we reported a facile and controllable
synthesis of Pt@Pd nanowires (NWs) in a non-compacted core–shell
structure with high electrocatalytic activity. In addition, polyethylenimine
(PEI)-capped reduced graphene oxide (rGO) nanoflakes provided large
binding sites for a network structure composed of interweaved Pt@Pd
nanowires and protected hemin from self-destruction, which empowered
Pt@Pd NWs-Hemin-PEI-rGO nanohybrids to own a large electroactive surface
area and great electrochemical property for CGA detection. The enzyme-free
electrochemical sensor based on Pt@Pd NWs-Hemin-PEI-rGO displayed
a favorable capacity for trace CGA detection with a detection limit
of 7.8 nM and a wide linear range of 0.5 μM to 4 mM. The exceptional
sensitivity and selectivity of the sensor made it accomplish the measurements
of chlorogenic acid in soft drinks and coffee with high consistency
of HPLC results. The satisfactory performance of the obtained sensor
enables it to be used for quality control and study of drug metabolism
in PD treatments.
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