In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process.

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In this paper attempts are made to address how bubble behaviour in a batch oscillatory ba ed column (OBC) contributes to the overall measured enhancement in mass transfer. A CCD camera is used to measure the bubble size distribution and the gas hold-up in the OBC. The experimental results of Sauter mean diameter and gas hold-up are correlated as a function of the power dissipation and super cial gas velocity, in order to allow for comparisons with published correlations for the mass transfer coe cient. In general, an increase in the oscillatory velocity causes an increase in the hold-up and a decrease in the Sauter mean diameter. Furthermore, we are able to show that the changes in the gas hold-up contribute more than the mean bubble size to the control of the mass transfer coe cient. ?

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