A comparative study of mass transfer in yeast for a batch pulsed baffled bioreactor and a stirred tank fermenter

Ni, Xiongwei; Gao, Siwen; Cumming, R. H.; Pritchard, D.W.

doi:10.1016/0009-2509(95)00050-f

Cited by 106 publications

(87 citation statements)

References 30 publications

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“…The overall gas-liquid volumetric mass transfer coe cient, k L a, in an OBC was found to be six times higher than that in a bubble column (Hewgill et al, 1993) and 75% higher than that in a stirred tank fermenter involving a yeast culture (Ni et al, 1995). However, no attempt was made in these studies to identify which characteristics of the gas phase in the OBC provided such enhancements in the mass transfer rate.…”

Section: Introductionmentioning

confidence: 94%

“…Gas-sparged stirred tanks, bubble columns and airlift columns are the most commonly used devices for enhancing gas-liquid mass transfer. The oscillatory ba ed column (OBC) is a relatively new mixing device and has recently been studied in gas-liquid applications (Hewgill, Mackley, Pandit, & Pannu, 1993;Ni, Gao, Cumming, & Pritchard, 1995). The OBC is based on the methodology of superimposing periodic uid oscillations onto a cylindrical column containing evenly spaced ori ce ba es.…”

Section: Introductionmentioning

confidence: 99%

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Gas hold-up and bubble diameters in a gassed oscillatory baffled column

Oliveira

2001

Chemical Engineering Science

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In this paper attempts are made to address how bubble behaviour in a batch oscillatory ba ed column (OBC) contributes to the overall measured enhancement in mass transfer. A CCD camera is used to measure the bubble size distribution and the gas hold-up in the OBC. The experimental results of Sauter mean diameter and gas hold-up are correlated as a function of the power dissipation and super cial gas velocity, in order to allow for comparisons with published correlations for the mass transfer coe cient. In general, an increase in the oscillatory velocity causes an increase in the hold-up and a decrease in the Sauter mean diameter. Furthermore, we are able to show that the changes in the gas hold-up contribute more than the mean bubble size to the control of the mass transfer coe cient. ?

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Gas hold-up and bubble diameters in a gassed oscillatory baffled column

Oliveira

2001

Chemical Engineering Science

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“…The intensity of mixing can be controlled by varying the oscillatory (amplitude and frequency) and geometrical (baffle spacing and baffle free area) conditions. It was found that the gas-liquid volumetric mass transfer coefficient in an OBC could be six times higher than that in a bubble column [14] and 75% higher than that in a stirred tank fermenter involving a yeast culture [15].…”

Section: Introductionmentioning

confidence: 95%

“…Extensive research on gas-liquid contacting has been undertaken in conventional bubble columns and stirred tank vessels [1][2][3][4][5][6][7][8][9][10][11][12][13], and the latter has been the standard device in fermentation industries worldwide. The oscillatory baffled column (OBC) has recently emerged as a viable alternative to those vessels, since it can provide enhanced mass transfer performance [14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of hydrodynamics on mass transfer in a gas–liquid oscillatory baffled column

Oliveira

2004

Chemical Engineering Journal

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In this paper, we present an experimental study on mass transfer of oxygen into water in an oscillatory baffled column (OBC). The objective of this work is to establish the contribution of individual parameters, such as the size of bubbles and the gas holdup, to the overall volumetric mass transfer coefficient (k L a). Our results show that the gas holdup is the most important factor. The liquid-side mass transfer coefficient (k L ) is calculated directly from the experimental measurements of gas holdup, Sauter mean diameter and k L a, and an increase of k L with D 32 is observed. The results also show that, above a critical level of fluid oscillation, the mass transfer coefficients are mainly governed by the oscillatory operating conditions, while independent of the type of gas sparger.

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“…An additional feature perhaps unique to OBCs is its linear scale-up in some particular applications, 15,[21][22][23] however no rules have yet been established in respect to scale-up of gas-liquid mixing in OBCs.…”

Section: Introductionmentioning

confidence: 99%

CO₂ Dissolution and Design Aspects of a Multiorifice Oscillatory Baffled Column

Pereira

Sousa

Alves

et al. 2014

Ind. Eng. Chem. Res.

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Dissolution of CO 2 in water was studied for a batch vertical multiorifice baffled column (MOBC) with varying orifice diameters (d 0 ) of 6.4−30 mm and baffle open area (α) of 15−42%. Bubble size distributions (BSDs) and the overall volumetric CO 2 mass transfer coefficient (K L a) were experimentally evaluated for very low superficial gas velocities, U G of 0.12− 0.81 mm s −1 , using 5% v/v CO 2 in the inlet gas stream at a range of fluid oscillations (f = 0−10 Hz and x 0 = 0−10 mm). Remarkably, baffles presenting large d o = 30 mm and α = 36%, therefore in the range typically found for single-orifice oscillatory baffled columns, were outperformed with respect to BSD control and CO 2 dissolution by the other baffle designs or the same aerated column operating without baffles or fluid oscillations. Flow visualization and bubble tracking experiments also presented in this study established that a small d o of 10.5 mm combined with a small value of α = 15% generates sufficient, strong eddy mixing capable of generating and trapping an extremely large fraction of microbubbles in the MOBC. This resulted in increased interfacial area yielding K L a values up to 65 ± 12 h −1 in the range of the U G tested, representing up to 3-fold increase in the rate of CO 2 dissolution when compared to the unbaffled, steady column. In addition, a modified oscillatory Reynolds number, Re o ′ and Strouhal number, St′ were presented to assist on the design and scale-up of gas−liquid systems based on multiorifice oscillatory baffled columns. This work is relevant to gas−liquid or multiphase chemical and biological systems relying on efficient dissolution of gaseous compounds into a liquid medium.

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A comparative study of mass transfer in yeast for a batch pulsed baffled bioreactor and a stirred tank fermenter

Cited by 106 publications

References 30 publications

Gas hold-up and bubble diameters in a gassed oscillatory baffled column

Gas hold-up and bubble diameters in a gassed oscillatory baffled column

Effect of hydrodynamics on mass transfer in a gas–liquid oscillatory baffled column

CO₂ Dissolution and Design Aspects of a Multiorifice Oscillatory Baffled Column

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A comparative study of mass transfer in yeast for a batch pulsed baffled bioreactor and a stirred tank fermenter

Cited by 106 publications

References 30 publications

Gas hold-up and bubble diameters in a gassed oscillatory baffled column

Gas hold-up and bubble diameters in a gassed oscillatory baffled column

Effect of hydrodynamics on mass transfer in a gas–liquid oscillatory baffled column

CO2 Dissolution and Design Aspects of a Multiorifice Oscillatory Baffled Column

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CO₂ Dissolution and Design Aspects of a Multiorifice Oscillatory Baffled Column