Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) infection and esophageal squamous cell carcinoma (ESCC) and related precursor lesions in a high-risk area of China. We conducted a crosssectional study among adult inhabitants of Linxian, China. All subjects were interviewed about potential risk factors, had the length of their esophagus sampled by a balloon cytology examination and underwent endoscopy with mucosal iodine staining and biopsy of all unstained lesions. A multivalent HPV hybridization probe, Digene Hybrid Capture II (Gaithersburg, MD), which recognizes high-risk types 16,18,31,33,35,39,45, 51, 52, 56, 58, 59 and 68, was used to determine the HPV infection status of the cytologic specimens, and the endoscopic biopsies were used to classify each subject's esophageal disease. 740 subjects completed the cytologic and endoscopic exams, and 702 had adequate cytologic and biopsy specimens. Using a cutpoint of 3.0 pg/ml of HPV DNA to define a positive test, HPV positivity was identified in 13% (61/475) of subjects without squamous dysplasia, 8% (8/102) with mild dysplasia, 7% (6/83) with moderate dysplasia, 16% (6/38) with severe dysplasia and zero (0/4) with invasive ESCC. Changing the cutpoint defining a positive test did not change the association of HPV infection and dysplasia grade. In this high-risk population, infection of esophageal cells with highrisk HPV types occurs in 13% of asymptomatic adults with no evidence of squamous dysplasia and a similar proportion of individuals with mild, moderate or severe dysplasia. This suggests that HPV infection is not a major risk factor for ESCC in this high-risk Chinese population. Further studies are warranted to determine if infection with this agent is associated with neoplastic progression in a subset of cases. ' 2006 Wiley-Liss, Inc.Key words: esophageal squamous cell carcinoma; HPV; Hybrid Capture II Esophageal cancer is the 6th leading cause of cancer death worldwide, with 462,000 new cases and 386,000 deaths each year. 1 Over 80% of esophageal cancers occur in developing countries, and most are of the squamous cell type. 1 The etiology of esophageal squamous cell carcinoma (ESCC) in high-risk regions remains poorly understood. Tobacco and alcohol, the dominant risk factors in low-risk countries, are not major determinants of ESCC in most high-risk populations. 2,3 Low consumption of fruits and vegetables, 2,4 micronutrient deficiencies, 5-7 low socioeconomic status 2,3 and family history of ESCC 3,8,9 appear to be the most consistent contributing factors in these populations. Poor oral hygiene, 10 polycyclic aromatic hydrocarbon exposure unrelated to tobacco smoke, 11,12 drinking hot liquids, 4,13,14 drinking mate tea 4 and exposure to fungal toxins 15 may also play a role, and other unk...

IntroductionOesophageal cancer (OC) is one of the most common cancers worldwide and about 50% of all new cases occurred in China. Population-based screening has been conducted in high-risk areas in China since 1970s, however, a few factors have limited the integration of the results from previous studies and the sharing of existing resources, such as the difference in screening methods and protocols, inconsistencies in questionnaires for risk factors investigation, lack of standards for sample collection and incomplete follow-up information.Methods and analysisThe National Cohort of Esophageal Cancer-Prospective Cohort Study of Esophageal Cancer and Precancerous Lesions based on High-Risk Population (NCEC-HRP) is a prospective cohort study of OC screening based on high-risk population in China supported by the National Key R&D Programme. Eight areas located at eastern, central and western China are selected as screening centres to represent three economical-geographical regions. All local residents aged 40–69 years in the selected areas are invited to take endoscopic examination and risk factors investigation unless they meet the exclusion criteria. The recruitment began on June 2017 and a total of 100 000 participants will be enrolled by December 2020 and all subjects will be followed for a long time. This study is designed as open-ended and has broad research aims. Summary statistics for baseline information will be reported after the completion of recruitment. We will develop a series of standards and guidelines for OC screening during the study. An open and shared research platform linked with epidemiological databases and biobank will be built up for further research.Ethics and disseminationThe study is approved by the Ethics Committee of Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (approval number 16-171/1250). The findings of the study will be disseminated through scientific peer-reviewed journals as well as the public via the study website (http://www.ncec-china.cn).Trial registration numberChiCTR-EOC-17010553; Pre-results.

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Sea ice adversely impacts nautical, logistical and scientific missions in polar regions. Ship navigation benefits from up-to-date sea ice analyses at both regional and local scales. This study presents a satellite-based sea ice navigation system (SatSINS) that integrates observations and scientific output from remote sensing and meteorological data to develop optimum marine navigational routes in sea ice-covered waters, especially in areas where operational ice information is usually scarce. The system and its applications are presented in the context of a decision-making process to optimize the routing of the RV Xuelong during her passage through Prydz Bay, East Antarctica during three trips in the austral spring of 2011-2013. The study assesses scientifically-generated remote sensing ice parameters for their operational use in marine navigation. Evaluation criteria involve identification of priority parameters, their spatio-temporal requirements in relation to navigational needs, and their level of accuracy in conjunction with the severity of ice conditions. Coarse-resolution ice concentration maps are sufficient to delineate ice edge and develop a safe route when ice concentration is less than 70%, provided that ice dynamics, estimated from examining the cyclonic pattern, is not severe. Otherwise, fine-resolution radar data should be used to identify and avoid deformed ice. Satellite data lagging one day behind the actual location of the ship was sufficient in most cases although the proposed route may have to be adjusted. To evaluate the utility of SatSINS, deviation of the actual route from the proposed route was calculated and found to range between 165 m to about 16.0 km with standard deviations of 2.8-6.1 km. Growth of land-fast ice has proven to be an essential component of the system as it was estimated using a thermodynamic model with input from a meteorological station.