We previously reported that supplementation with dietary tetrahydrocurcumin (THC), the major active metabolite of curcumin (Cur), can improve allergic inflammation in asthmatic mice. Dietary factors can shape the gut microbiota...
Allergic asthma is a refractory disease that affects hundreds of millions of people worldwide. Betanin is a natural plantderived nutrient and possesses health-promoting properties. The effects of betanin on allergic asthma remain unknown. Herein, the effects and mechanisms of betanin on allergic asthma were explored in ovalbumin (OVA)-induced BALB/c mice. Betanin in doses of 0, 20, 60, and 180 mg/kg was applied. Peripheral inflammatory cells, IgE, pulmonary pathology, T cell subsets, cytokine levels, protein expressions of the cAMP−PKA−CREB/CREM pathway, and gut microbial profile were measured. The 60 and 180 mg/kg/ day betanin doses significantly downregulated IgE, eotaxin, eosinophil infiltration, mucus hyperproduction, and Th2. A 180 mg/kg/ day betanin dose also significantly reduced percentages of Th17, Tc17, and Tc2 and Th2-and Th17-signature cytokines and upregulated the cAMP−PKA−CREB pathway. Additionally, 20 mg/kg/day betanin altered the gut microbial profile. In conclusion, betanin dose-dependently alleviated allergic asthma and upregulated the cAMP−PKA−CREB pathway in mice. This study provides a novel nutritional strategy to treat allergic asthma.
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