Protocatechuic acid supplement alleviates allergic airway inflammation by inhibiting the IL-4Rα–STAT6 and Jagged 1/Jagged2–Notch1/Notch2 pathways in allergic asthmatic mice

Li, Qin; Wu, Yinfan; Guo, Xingyue; Wang, Ren; Mao, Yu-Heng; Zhao, Yimin; Zou, Jinchao; Li, Chunwei; Chen, Yanqiu; Yang, Yan

doi:10.1007/s00011-020-01379-1

Cited by 11 publications

(4 citation statements)

References 61 publications

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“…IL-4 and IL-13 promote the differentiation of B cells and the synthesis of immunoglobulin E (IgE). IL-5 can induce the chemotaxis, recruitment, differentiation, and release of active substances of eosinophils as well as cooperate with IL-4 to stimulate B cells to synthesize IgE (Alrumaihi et al, 2020;Li et al, 2020). In our research, two m6A patterns (clusterA and clusterB) were identified based on the 11 significant m6A regulators using the consensus clustering method.…”

Section: Discussionmentioning

confidence: 93%

Significance of RNA N6-Methyladenosine Regulators in the Diagnosis and Subtype Classification of Childhood Asthma Using the Gene Expression Omnibus Database

et al. 2021

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RNA N6-methyladenosine (m6A) regulators play important roles in a variety of biological functions. Nonetheless, the roles of m6A regulators in childhood asthma remain unknown. In this study, 11 significant m6A regulators were selected using difference analysis between non-asthmatic and asthmatic patients from the Gene Expression Omnibus GSE40888 dataset. The random forest model was used to screen five candidate m6A regulators (fragile X mental retardation 1, KIAA1429, Wilm’s tumor 1-associated protein, YTH domain-containing 2, and zinc finger CCCH domain-containing protein 13) to predict the risk of childhood asthma. A nomogram model was established based on the five candidate m6A regulators. Decision curve analysis indicated that patients could benefit from the nomogram model. The consensus clustering method was performed to differentiate children with asthma into two m6A patterns (clusterA and clusterB) based on the selected significant m6A regulators. Principal component analysis algorithms were constructed to calculate the m6A score for each sample to quantify the m6A patterns. The patients in clusterB had higher m6A scores than those in clusterA. Furthermore, we found that the patients in clusterA were linked to helper T cell type 1 (Th1)-dominant immunity while those in clusterB were linked to Th2-dominant immunity. In summary, m6A regulators play nonnegligible roles in the occurrence of childhood asthma. Our investigation of m6A patterns may be able to guide future immunotherapy strategies for childhood asthma.

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Section: Discussionmentioning

confidence: 93%

Significance of RNA N6-Methyladenosine Regulators in the Diagnosis and Subtype Classification of Childhood Asthma Using the Gene Expression Omnibus Database

et al. 2021

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“…No side effects [263] Based on the findings from in vitro studies indicating the immunomodulatory activities of flavonoids, these polyphenolic compounds should also be considered as po-tentially effective preventive and therapeutic agents for asthma [251]. Indeed, several studies in OVA-induced asthmatic mice have shown that luteolin, hesperidin, glabridin, green tea catechins, and rosmarinic acid can significantly reduce both symptoms of bronchoconstriction and allergic airway inflammation level by decreasing the Th2 cytokine level, inflammatory cells infiltration, mucus secretion, interstitial fibrosis, and collagen deposition, accompanied by alleviation of airway hyperresponsiveness and lung function improvement [136,160,[278][279][280][281][282][283][284]. Recently, in a house dust mite (HDM)-induced asthma model, epigallocatechin gallate (EGCG), the major flavonoid extracted from green tea, has been demonstrated to decrease specific IgE in the serum while increasing IL-10 levels in the BALF, upregulate the amount of Treg cells and expression of Foxp3 mRNA in the lung tissue, thus effectively ameliorating tissue injury, airway inflammation and airway hyperresponsiveness [285,286].…”

Section: Asthmamentioning

confidence: 99%

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Dębińska,

Sozańska

2023

Nutrients

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In light of the constantly increasing prevalence of allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for the development and progression of these diseases. Nowadays, much attention has been paid to the development of dietary interventions using natural substances with anti-allergy activities. In this respect, dietary polyphenols have been studied extensively as one of the most prominent natural bioactive compounds with well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to discuss the mechanisms underlying the potential anti-allergic actions of polyphenols related to their ability to reduce protein allergenicity, regulate immune response, and gut microbiome modification; however, these issues need to be elucidated in detail. This paper reviews the current evidence from experimental and clinical studies confirming that various polyphenols such as quercetin, curcumin, resveratrol, catechins, and many others could attenuate allergic inflammation, alleviate the symptoms of food allergy, asthma, and allergic rhinitis, and prevent the development of allergic immune response. Conclusively, dietary polyphenols are endowed with great anti-allergic potential and therefore could be used either for preventive approaches or therapeutic interventions in relation to allergic diseases. Limitations in studying and widespread use of polyphenols as well as future research directions are also discussed.

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“…Three compounds, namely, ginsenoside Rb1 ( Zhang et al, 2018 ), luteolin ( Wang et al, 2020b ), and physalin D ( Ding et al, 2019 ) exhibited potential therapeutic effects on coronary artery disease, inflammation, and imbalance of macrophage polarization-related diseases. The others preferentially executed their primary role for downregulation of STAT6 signaling in the treatment of various diseases, for instance, atopic dermatitis symptoms ( Sung and Kim, 2018 ), cancer metastasis ( Yang et al, 2018 ), allergic airway inflammation ( Chen et al, 2018 ; Li et al, 2020d ), asthma ( Ma et al, 2020 ), allergic asthma ( Chen et al, 2017 ; Ma et al, 2019 ), diabetes-associated inflammation ( Oh et al, 2020 ), chronic kidney disease ( Li et al, 2020e ), cervical cancer ( Duan et al, 2021 ), inflammation ( Liu et al, 2018 ), insulin resistance ( Subash-Babu and Alshatwi, 2018 ), and AD ( Choi et al, 2020 ).…”

Section: Traditional Chinese Medicines or Herbs Or Natural Compounds ...mentioning

confidence: 99%

Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling

et al. 2022

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JAK/STAT signaling pathways are closely associated with multiple biological processes involved in cell proliferation, apoptosis, inflammation, differentiation, immune response, and epigenetics. Abnormal activation of the STAT pathway can contribute to disease progressions under various conditions. Moreover, tofacitinib and baricitinib as the JAK/STAT inhibitors have been recently approved by the FDA for rheumatology disease treatment. Therefore, influences on the STAT signaling pathway have potential and perspective approaches for diverse diseases. Chinese herbs in traditional Chinese medicine (TCM), which are widespread throughout China, are the gold resources of China and have been extensively used for treating multiple diseases for thousands of years. However, Chinese herbs and herb formulas are characterized by complicated components, resulting in various targets and pathways in treating diseases, which limits their approval and applications. With the development of chemistry and pharmacology, active ingredients of TCM and herbs and underlying mechanisms have been further identified and confirmed by pharmacists and chemists, which improved, to some extent, awkward limitations, approval, and applications regarding TCM and herbs. In this review, we summarized various herbs, herb formulas, natural compounds, and phytochemicals isolated from herbs that have the potential for regulating multiple biological processes via modulation of the JAK/STAT signaling pathway based on the published work. Our study will provide support for revealing TCM, their active compounds that treat diseases, and the underlying mechanism, further improving the rapid spread of TCM to the world.

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Protocatechuic acid supplement alleviates allergic airway inflammation by inhibiting the IL-4Rα–STAT6 and Jagged 1/Jagged2–Notch1/Notch2 pathways in allergic asthmatic mice

Cited by 11 publications

References 61 publications

Significance of RNA N6-Methyladenosine Regulators in the Diagnosis and Subtype Classification of Childhood Asthma Using the Gene Expression Omnibus Database

Significance of RNA N6-Methyladenosine Regulators in the Diagnosis and Subtype Classification of Childhood Asthma Using the Gene Expression Omnibus Database

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling

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