Objectives
Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout.
Methods
This is a retrospective analysis of 147 routinely collected data on hospital patients with obesity who underwent bariatric surgery. The body weight and SUA were measured at baseline and after surgery at 1–7 days, 1, 3, 6 and 12 months.
Results
The mean (95% CI) weight reduction of 147 patients was 30.7 (28.7, 32.7) kg 1 year after surgery (P < 0.001). SUA decreased rapidly from 419.0 (400.1, 437.8) µmol/l at baseline to 308.4 (289.6, 327.2) µmol/l at 1–7 days, flared up to 444.8 (423.9, 465.6) µmol/l at 1 month, then decreased again to 383.8 (361.5, 406.1) µmol/l at 3 months, 348.9 (326.3, 371.5) µmol/l at 6 months and 327.9 (305.3, 350.5) µmol/l at 12 months (P < 0.001). Similar trends but more rapid reductions were observed in 55 hyperuricaemia patients and 25 gout patients. All 25 gout patients had an elevated SUA above the therapeutic target (≥360µmmol/l) at baseline, but in 10 patients it was reduced below this target at 12 months. The mean reduction (95% CI) of SUA in all patients and gout patients was 84.3 (63.1–105.4) and 163.6 (103.9, 223.3) µmmol/l, respectively.
Conclusion
Bariatric surgery significantly reduces body weight and SUA for obese patients with hyperuricaemia and gout. Gout may be considered as an indicator for this surgical treatment in people with severe obesity.
Particulate matter (PM) pollution has become a serious threat to human health. Accordingly, an air filtration media that can efficiently remove particulate matter should be developed immediately. Nanofibrous membrane filter prepared by electrospinning technology has nanoscale diameter, high specific surface area, and relatively high porosity, which are suitable for dust removal. This paper explored the effects of electrospinning parameters on the microscopic morphology, fiber diameter, and pore size of polyacrylonitrile (PAN) nanofibrous membranes, including polymer solution concentration, applied voltage, and tip-to-collector distance. Thereafter, filtration efficiencies of electrospun PAN fibrous membrane and Polytetrafluoroethylene (PTFE), Cellulose acetate (CA), Nylon commercial filter were compared by removing smoke PMs. Results showed that fiber diameter and pore size increase with increasing concentration but decrease with increasing distance. With an increase in applied voltage, fiber diameter and pore size first decreased and increased thereafter. Lastly, filtration experimental results showed that filtration efficiency of electrospun PAN nanofibrous membranes was higher than that of those commercial filter membranes for ultra fine dust (0.3–0.5 μm).
Primary plasma cell leukemia (PPCL) is one of the most challenging diseases for hematologists.A 65-year-old Chinese male with a history of chronic kidney disease and anemic appearance was admitted.He was diagnosed with plasma cell leukemia. Peripheral blood cells smearing showed piles of plasma cells with cloud-like agglutination. EDTA-dependent plasma cells agglutination is a rare phenomenon in vitro.We reported a case of plasma cell leukemia characterized by plasma cell agglutination, which has never been reported. This case reminded the laboratory physicians who master the blood cell analyzer should have the ability to comprehensively diagnose hematological diseases, and at the same time strictly implement the "Reexamination Rules for Blood Cells".
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.