An
efficient catalytic protocol based on reusable MgAl-layered
double hydroxides has been developed for the synthesis of multi-functionalized
oxazolines via the cyclocondensation of amidines and aminoalcohols.
The developed method has a broad substrate scope and excellent functional
group tolerance and uses a reusable catalyst. The catalyst can be
conveniently recycled by filtration and reused for at least five times
without obvious deactivation. Additionally, the selective ortho C–H silylation of oxazolines was performed
using Ru(II) as the catalyst and triethyl silane as the silylating
reagent, which proved to be a convenient and practical method for
the synthesis of versatile organosilyl-functionalized oxazolines with
advantageous biological and physical properties.
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