Cancer multimodal treatment by combining the effects of different theranostics agents can efficiently improve treatment efficacy and reduce side effects. In this work, we demonstrate the theranostics nanodevices on the basis of Cu-loaded polydopamine nanoparticles (CuPDA NPs), which are able to offer magnetic resonance imaging (MRI)-guided thermochemotherapy (TCT). Systematical studies reveal that after Cu ions loading, the molar extinction coefficient of PDA NPs is greatly enhanced by 4 times, thus improving the performance in photothermal therapy. Despite Cu ions being toxic, the release of Cu is mainly stimulated in acidic environment. Once the NPs deposit in the slightly acidic tumor microenvironment (pH ≈ 6.5-6.8), the release rate boosts ∼30%, which effectively avoids the systematic toxicity during chemotherapy. Meanwhile, due to the increment of the electron-proton dipole-dipole interaction correlation time τ, the spin-lattice relaxation time (T) for PDA NPs is found to be shortened by Cu loading, which boosts the longitudinal relaxivity (r). Hence, CuPDA NPs can be used as T-weighted contrast agent in MRI. In addition, due to the naturally existing DA in the human body with stealth effect, CuPDA NPs have an outstanding tumor retention rate as high as 8.2% ID/g. Further in vitro and in vivo tests indicate that CuPDA NPs possess long blood circulation time, good photothermal and physiological stability, and biocompatibility, which are potential nanodevices for MRI-guided TCT with minimal side effects.

On the basis of cytochrome c-induced self-assembled graphene quantum dots, we demonstrate a novel fluorescent biosensor for trypsin with remarkable fluorescence enhancement, as well as high selectivity and sensitivity.

Recently, a great variety of aggregation-induced emission (AIE)-active molecules has been utilized to design bioprobes for label-free fluorescent turn-on aptasensing with high sensitivity. However, due to nonspecific binding interaction between aptamer and AIE probe, these AIE-based aptasensors have nearly no selectivity, thereby significantly limiting the development. In this work, a 9,10-distyrylanthracene with two ammonium groups (DSAI) is synthesized as a novel AIE probe, and the fluorescent aptasensor based on DSAI and graphene oxide (GO) is developed for selective and sensitive sensing of targeted DNA and thrombin protein. Given its AIE property and high selectivity and sensitivity, this aptasensor can be also exploited to detect other targets.

Folic acid-functionalized polymer dots with aggregation induced emission features (AIE Pdots), which show high fluorescence efficiency and little toxicity to living cells, which possess a good capability for targeted HeLa intracellular imaging.

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malononitrile) (TPA-AN-TPM) with near-infrared emission was synthesized by coating a disc-like red emission fluorophore with a propeller-shaped AIE fluorophore. The ultrabright red AIE dots TPA-AN-TPM@PS-PVP (TPA-AN-TPM in poly(styrene)-poly(4-vinylpyridine) nanoparticles) with an absolute quantum yield of 12.9% were fabricated by using the AIE molecule TPA-AN-TPM as the core and one biocompatible polymer PS-PVP as the encapsulation matrix. The AIE dots are mono-dispersed with an average diameter of 25 nm, and are stable in an aqueous suspension. In particular, the AIE dots can stain both the cytoplasm and the nuclei with a strong red fluorescence signal, and pose little toxicity to living cells.

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