Background Global migration from regions where strongyloidiasis and schistosomiasis are endemic to non-endemic countries has increased the potential individual and public health effect of these parasitic diseases. We aimed to estimate the prevalence of these infections among migrants to establish which groups are at highest risk and who could benefit from screening. MethodsWe did a systematic review and meta-analysis of strongyloidiasis and schistosomiasis prevalence among migrants born in endemic countries. Original studies that included data for the prevalence of Strongyloides or Schistosoma antibodies in serum or the prevalence of larvae or eggs in stool or urine samples among migrants originating from countries endemic for these parasites and arriving or living in host countries with low endemicity-specifically the USA, Canada, Australia, New Zealand, Israel, and 23 western European countrieswere eligible for inclusion. Pooled estimates of the prevalence of strongyloidiasis and schistosomiasis by stool or urine microscopy for larvae or eggs or serum antibodies were calculated with a random-effects model. Heterogeneity was explored by stratification by age, region of origin, migrant class, period of study, and type of serological antigen used. Findings 88 studies were included. Pooled strongyloidiasis seroprevalence was 12•2% (95% CI 9•0-15•9%; I² 96%) and stool-based prevalence was 1•8% (1•2-2•6%; 98%). Migrants from east Asia and the Pacific (17•3% [95% CI 4•1-37•0]), sub-Saharan Africa (14•6% [7•1-24•2]), and Latin America and the Caribbean (11•4% [7•8-15•7]) had the highest seroprevalence. Pooled schistosomiasis seroprevalence was 18•4% (95% CI 13•1-24•5; I² 97%) and stool-based prevalence was 0•9% (0•2-1•9; 99%). Sub-Saharan African migrants had the highest seroprevalence (24•1•% [95% CI 16•4-32•7]).Interpretation Strongyloidiasis affects migrants from all global regions, whereas schistosomiasis is focused in specific regions and most common among sub-Saharan African migrants. Serological prevalence estimates were several times higher than stool estimates for both parasites. These data can be used to inform screening decisions for migrants and support the use of serological screening, which is more sensitive and easier than stool testing.

Short-term therapy with vitamin C improves mood and reduces psychological distress in acutely hospitalized patients with a high prevalence of hypovitaminosis C and D. No conclusion is possible regarding the effects of vitamin D because the dose and duration of therapy were insufficient to raise 25(OH)D concentrations into the normal range. This trial was registered at clinicaltrials.gov as NCT01630720.

Over the last few years hot stamping for its high strength, lightweight characteristics has developed at an alarming rate, At the same time the measurement process a higher demand. Compared with the traditional three-dimensional coordinate measurement, Hand-held Blue structured Light 3D measurement technology for its fast, high precision, good flexibility, etc., has become the best choice of high-strength steel stamping in non-contact 3D measurement and accuracy detection. This paper developed a set of holding blue light 3D measurement system. The system project blue structured pattern to the surface of the object, and captured by two high-speed cameras synchronized. Then using the grabbed pictures reconstruct 3D topography of the object. Blue light projection technology can eliminate the use of influence of different surface reflectance measurement accuracy, So that a single measurement accuracy of 0.02mm, overall measurement accuracy of 0.05mm / m, Single measurement time is less than 0.12 seconds. This measuring system can be widely used in the rapid detection of various types of three-dimensional measurement and precision casting.

This study examined the role of endothelin-1 (ET-1) in recruiting infl ammatory cells to the lung after induction of injury with either lipopolysaccharide (LPS) or cigarette smoke. Hamsters injected with either ET-1 or its precursor peptide (Big ET-1) prior to treatment with LPS or cigarette smoke had markedly increased concentrations of neutrophils in bronchoalveolar lavage fl uid (BALF) despite a reduction in total numbers of BALF leukocytes. Furthermore, the effect of ET-1 on smoke-exposed animals was reversed by addition of an endothelin-A receptor antagonist. These results are consistent with preferential recruitment of neutrophils by ET-1, and suggest that inhibition of this proinfl ammatory mediator may decrease acute pulmonary infl ammation associated with cigarette smoke and other pulmonary toxins.

Hypovitaminosis C and D are highly prevalent in acute‐care hospitals, but their clinical implications have not been investigated. Because deficiencies of these vitamins can adversely affect mood, we conducted a double‐blind randomized clinical trial to determine the effect of vitamin C (500 mg twice daily) or D (5000 IU daily) supplementation on psychological status, as assessed using two different validated instruments. At baseline, 73% of patients had a subnormal plasma vitamin C concentration (< 28.4 μM) and 79% had a subnormal plasma 25OHD concentration (< 75 nM). Vitamin C provision for a mean of 8.2 days (n = 26) normalized plasma vitamin C concentrations (P < 0.0001) and resulted in a 71% reduction in Profile of Mood StatesR total mood disturbance score (from 24.0 ± 18.2 to 6.9 ± 14.4, mean ± SD; P = 0.0002) and a 51% reduction in psychological distress as measured using the Distress Thermometer (from 4.5 ± 2.9 to 2.2 ± 2.2; P = 0.0002). By contrast, high‐dose vitamin D provision for a mean of 8.1 days (n = 26) increased plasma 25OHD concentrations (P < 0.0001), but not into the normal range, and had statistically insignificant effects on mood (21.7 ± 17.3 to 14.6 ± 17.7; P = 0.067) and distress (3.7 ± 2.6 to 3.4 ± 2.8; P = 0.45).ConclusionHypovitaminosis C and D are highly prevalent in acutely hospitalized patients. Vitamin C supplementation improves mood and reduces distress in these patients. Supported by the Lotte and John Hecht Foundation and a Faculty of Medicine student research bursary.Grant Funding Source: Lotte and John Hecht Foundation