A novel and green strategy for the synthesis of acylated quinazolinone derivatives via photo-induced decarboxylative cascade radical acylation/cyclization of quinazolinone bearing unactivated alkenes has been developed. The protocol provides a...
A mild and metal-free protocol for visible-light induced intramolecular radical cyclization of N-allyl(propargyl)-2-bromo-2,2-difluoro-N-arylacetamide has been developed.
A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature and gave a variety of C-3-functionalized 2-amino-1,4-naphthoquinone derivatives in moderate to excellent yields. Moreover, mechanistic studies revealed that the reaction is driven by the formation of an electron donor−acceptor (EDA) complex.
An efficient and novel method for
regioselective hydroxydifluoroacetamidation
of alkenes with bromodifluoroacetamides has been achieved via a tandem
radical pathway mediated by photoredox catalysis under metal-free
conditions. This transformation proceeded smoothly in the presence
of Rhodamine 6G, affording a series of α,α-difluoro-γ-hydroxyacetamides
in moderate to excellent yields. The significant advantages of this
protocol are the low-cost photocatalyst, readily available starting
materials, synthetic convenience, and wide functional group compatibility.
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