Integral imaging is a promising three-dimensional (3D) imaging technique that captures and reconstructs light field information. Microlens arrays are usually used for the reconstruction process to display 3D scenes to the viewer. However, the inherent chromatic aberration of the microlens array reduces the viewing quality, and thus, broadband achromatic imaging remains a challenge for integral imaging. Here, we realize a silicon nitride metalens array in the visible region that can be used to reconstruct 3D optical scenes in the achromatic integral imaging for white light. The metalens array contains 60 × 60 polarization-insensitive metalenses with nearly diffraction-limited focusing. The nanoposts in each high-efficiency (measured as 47% on average) metalens are delicately designed with zero effective material dispersion and an effective achromatic refractive index distribution from 430 to 780 nm. In addition, such an achromatic metalens array is composed of only a single silicon nitride layer with an ultrathin thickness of 400 nm, making the array suitable for on-chip hybrid-CMOS integration and the parallel manipulation of optoelectronic information. We expect these findings to provide possibilities for full-color and aberration-free integral imaging, and we envision that the proposed approach may be potentially applicable in the fields of high-power microlithography, high-precision wavefront sensors, virtual/augmented reality and 3D imaging.

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Healing of cutaneous wounds is a complex and well-coordinated process requiring cooperation among multiple cells from different lineages and delicately orchestrated signaling transduction of a diversity of growth factors, cytokines, and extracellular matrix (ECM) at the wound site. Most skin wound healing in adults is imperfect, characterized by scar formation which results in significant functional and psychological sequelae. Thus, the reconstruction of the damaged skin to its original state is of concern to doctors and scientists. Beyond the traditional treatments such as corticosteroid injection and radiation therapy, several growth factors or cytokines-based anti-scarring products are being or have been tested in clinical trials to optimize skin wound healing. Unfortunately, all have been unsatisfactory to date. Currently, accumulating evidence suggests that the ECM not only functions as the structural component of the tissue but also actively modulates signal transduction and regulates cellular behaviors, and thus, ECM should be considered as an alternative target for wound management pharmacotherapy. Of particular interest are small leucine-rich proteoglycans (SLRPs), a group of the ECM, which exist in a wide range of connecting tissues, including the skin. This manuscript summarizes the most current knowledge of SLRPs regarding their spatial-temporal expression in the skin, as well as lessons learned from the genetically modified animal models simulating human skin pathologies. In this review, particular focus is given on the diverse roles of SLRP in skin wound healing, such as anti-inflammation, pro-angiogenesis, pro-migration, pro-contraction, and orchestrate transforming growth factor (TGF)b signal transduction, since cumulative investigations have indicated their therapeutic potential on reducing scar formation in cutaneous wounds. By conducting this review, we intend to gain insight into the potential application of SLRPs in cutaneous wound healing management which may pave the way for the development of a new generation of pharmaceuticals to benefit the patients suffering from skin wounds and their sequelae.

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The NMR method described here is effective for milk authenticity identification, and the study demonstrates that the NMR-based milk metabolite analysis approach provides a means of detecting adulteration at expected levels and can be used for dairy quality monitoring. © 2016 Society of Chemical Industry.

The human riboflavin transporter-3 (encoded by SLC52A3) plays a prominent role in riboflavin absorption. Interestingly, abnormal expression patterns of SLC52A3 in multiple types of human cancers have been recently noted. However, the molecular mechanisms underlying its dysregulation remain unclear. In this study, we find that SLC52A3 has two transcript variants that differ in the transcriptional start site, and encode different proteins: SLC52A3a and SLC52A3b. Importantly, aberrant expressions of SLC52A3 are associated with stepwise development of esophageal squamous cell carcinoma (ESCC) as well as the survival rates of ESCC patients. Functionally, SLC52A3a, but not SLC52A3b, strongly promotes the proliferation and colony formation of ESCC cells. Furthermore, SLC52A3 5′-flanking regions contain NF-κB p65/Rel-B-binding sites, which are crucial for mediating SLC52A3 transcriptional activity in ESCC cells. Chromatin immunoprecipitation and electrophoretic mobility shift assay reveal that p65/Rel-B bind to 5′-flanking regions of SLC52A3. Accordingly, NF-κB signaling upregulates SLC52A3 transcription upon TNFα stimulation. Taken together, these results elucidate the mechanisms underlying SLC52A3 overexpression in ESCC. More importantly, our findings identify SLC52A3 as both a predictive and prognostic biomarker for this deadly cancer.Electronic supplementary materialThe online version of this article (10.1007/s00018-018-2757-4) contains supplementary material, which is available to authorized users.

This paper uses the data of Cluster from 2001 to 2009 to study the polytropic processes of central plasma sheet (CPS) ions. We first adopt the approach of MHD Bernoulli integral (MBI) to identify homogeneous streamflow tubes (quasi-invariant MBI regions) and then calculate the polytropic index of ions for those streamflow tubes whose outward electromagnetic energy ratios δ < 0.05. The central plasma sheet is actually a complicated system, which comprises many streamflow tubes with different polytropic relations and the transition layers in between. The polytropic indexes of the CPS ions range from 0.1 to 1.8 and have a quasi-Gaussian distribution. The median polytropic index is 0.93 for AE < 200 nT and 0.91 for AE ≥ 200 nT. Thus, there is no obvious difference between the polytropic indexes of the quiet time and the substorm time CPS ions, which suggests that the thinning and thickening processes of plasma sheet during substorm times do not change obviously the polytropic relation of the CPS ions. The statistical analysis using different δ (δ < 0.05, 0.025, and 0.01) shows that the outward emission of electromagnetic energy is an effective cooling mechanism and can make the polytropic index to decrease and shift toward isobaric. It is inferred that the CPS ions as a whole much likely behave in a way between isobaric and isothermal.

This paper uses Cluster data during the period from 2001 to 2010 to study the polytropic processes of magnetosheath ions. Utilizing the method of homogeneous magnetohydrodynamic (MHD) Bernoulli integral (MBI), we first identify streamflow tubes, then use the constant of polytropic relation to guarantee that the streamflow tube experiences an unchanged polytropic process, and finally determine the polytropic index of ions in these streamflow tubes. The statistical results show that the magnetosheath is a complicated system in which the polytropic index of ions ranges from −2 to 3. The polytropic index distribution of ions is dependent on the electromagnetic energy flux perpendicular to the streamline. The median polytropic index of ions in the magnetosheath is 0.960, 0.965, and 0.974 for perpendicular electromagnetic energy ratio δE × B < 5%, δE × B < 3%, and δE × B < 1%, respectively. There are two basic polytropic processes in the magnetosheath: the dominant isothermal process and the isobaric process. When there is no exchange of electromagnetic energy between neighboring streamflow tubes, the magnetosheath ions are isothermal. However, when the perpendicular electromagnetic energy ratio increases, the isobaric polytropic process starts to emerge. The magnetosheath ion flows are highly localized because most streamflow tubes experiencing same polytropic processes last less than 60 s. Thus, the polytropic index of magnetosheath ion flows is highly variable.