Herein, a new reductive-responsive pillar[5]arene-based, single-molecule-layer polymer nanocapsule is constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in a reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer drug shows excellent inhibition for tumor cell proliferation and exhibits low side effect on normal cells. This work not only demonstrates the development of a new reductive-responsive single molecular layer polymer nanocapsule for anticancer drug targeting delivery but also extends the design of smart materials for biomedical applications.
Poly(dimethylsiloxane)
(PDMS) as one of the electron-drawing materials
has been widely used in triboelectric nanogenerators (TENG), which
is expected to generate electron through friction and required to
endure dynamic loads. However, the nature of the siloxane bond and
the low interchain interaction between the methyl side groups result
in low fracture energy in PDMS elastomers. Here, a strategy that combined
the advantages of the dynamic of hierarchical hydrogen bonding and
phase-separation-like structure was adopted to improve the toughness
of PDMS elastomers. By varying both stronger and weaker hydrogen bonding
within the PDMS network, a series of super tough (up to 24,000 J/m2), notch-insensitive, transparent, and autonomous self-healable
elastomers were achieved. In addition, a hydrophilic polymeric material
(PDMAS-U10) was synthesized as the conductive layer. A transparent
TENG was fabricated by sandwiching the PDMAS-U10 between two pieces
of the PDMS elastomer. Despite its hydrophilic nature, PDMAS-U10 exhibit
strong adhesion interaction with hydrophobic PDMS elastomers. As such,
a tough (16,500 J/m2), self-healable (efficiency ∼97%),
and transparent triboelectric nanogenerator was constructed. A self-powered
system employing the TENG is also demonstrated in this work.
Self-healing, one of the exciting properties of materials, is frequently used to repair the damage of biological and artificial systems. Here we have used enzymatic catalysis approaches to develop a fast self-healing hydrogel, which has been constructed by dynamic aldimine cross-linking of pillar[5]arene-derivant and dialdehyde-functionalized PEG followed by encapsulation of glucose oxidase (GOx) and catalase (CAT). In specific, the two hydroxyl groups at terminal of PEG are functionalized with benzaldehydes that can interact with amino-containing pillar[5]arene-derivant through dynamic aldimine cross-links, resulting in reversible dynamic hydrogels. Modulus analysis indicated that storage modulus (G') and loss modulus (G″) of the hydrogel increased obviously as the concentration of dialdehyde-functionalized PEG (DF-PEG) increased or the pH values decreased. Once glucose oxidase (GOx) and catalase (CAT) are located, the hydrogel could be fast repaired, with self-healing efficiency up to 100%. Notably tensile test showed that the repair process of pillararene-based hydrogel can finish in several minutes upon enzyme catalysis, while it needed more than 24 h to achieve this recovery without enzymes. This enzyme-regulated self-healing hydrogel would hold promise for delivering drugs and for soft tissue regeneration in the future.
The significant disability and fatality rate of diabetes chronic wounds necessitates the development of efficient diabetic wound healing techniques. Present oxygen treatment for wound healing is restricted by issues such...
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