Zhang Jie-Min(张洁敏) a) , Guan Qun(管 群) b) , Tang Li-Ming(汤黎明) b) , Liu Tie-Bing(刘铁兵) b) † , Liu Hong-Xing(刘红星) a) ‡ , Huang Xiao-Lin(黄晓林) a) , and Si Jun-Feng(司峻峰) a)
Purpose:This work proposed a nearest neighbor estimation method to track the respiration-induced tumor motion.Methods:Based on the simultaneously collected motion traces of external surrogate and internal target during the modeling phase prior to treatment, we first obtain the nearest neighbors of the current surrogate in external space. Subsequently, the concurrent targets in internal space are determined and used to estimate the current target position. The method was validated on 71 cases that were from 3 open access databases. In addition, to evaluate the method’s estimation and prediction accuracy, we compared the method with other works.Results:Except for 2 cases, the nearest neighbor estimation achieved the root-mean-square error of <3 mm. The comparison indicated that the method had better estimation accuracy than polynomial model and good prediction performance.Discussion:The 2 exceptive cases were further analyzed for failure causes. We inferred that one was because of the lack of estimating new target in our method, and the other one was because of the mistake during data collection. Accordingly, the potential solutions were suggested. Besides, the method’s estimation for surrogate outliers, effects of modeling length, calibration, and extension were discussed.Conclusion:The results demonstrated nearest neighbor estimation’s effectiveness. Except for this, the method imposes no restrictions on the modality of the pretreatment target images and does not assume a specific correspondence function between the surrogate and the target. With only 1 critical parameter, this nearest neighbor estimation method is easy to implement in clinical setting and thus has potential for broad applications.
Symbolic dynamics method and time reversal asymmetry analysis are both important approaches in the study of heartbeat interval series. However, there is limited research work reported on combining these two methods. We provide a method of time reversal asymmetry analysis which focuses on the differences between the forward and backward embedding "m words" after the operation of equiprobable symbolization. To investigate the total amplitude as well as the distribution features of the difference, four indices are proposed. Based on the application to simulation series, we found that these measures can successfully detect time reversal asymmetry in chaos series. With application to human heartbeat interval series (RR series), it is suggested that the distribution features of the forward-backward difference can sensitively capture the dynamical changes caused by diseases or aging. In particular, the index E(D), which reflects the random degree of the forward-backward difference distribution, can significantly discriminate healthy subjects from diseased ones. We conclude that RR series from healthy subjects show more asymmetry in temporal structure on the original time scale from the perspective of equiprobable symbolization, whereas diseases account for loss of this asymmetry.
BackgroundAlmost all promising non-invasive foetal ECG extraction methods involve accurately determining maternal ECG R-wave peaks. However, it is not easy to robustly detect accurate R-wave peaks of the maternal ECG component in an acquired abdominal ECG since it often has a low signal-to-noise ratio (SNR), sometimes containing a large foetal ECG component or other noises and interferences. This paper discusses, under the condition of acquiring multi-channel abdominal ECG signals, how to improve the robustness of maternal ECG R-wave peak detection.MethodsOn the basis of summarising the current single channel ECG R-wave peak detection methods, the paper proposed a specific fusion algorithm of detected multi-channel maternal ECG R-wave peak locations. The proposed entire algorithm was then tested using two databases; one database, created by us, was composed of 343 groups of 8-channel data collected from 78 pregnant women, and the other one, called the challenge database, was from the Physionet/Computing in Cardiology Challenge 2013, including 175 groups of 4-channel data. When using these databases, each group of data was classified into two parts, called the training part and the validation test part respectively; the training part was the first 8.192 s of each group of data and the validation test part was the next 8.192 s.ResultsTo show the results, three evaluation parameters—sensitivity (Se), positive predictive value (PPV) and F1—are used. The validation test results for the database we collected are Se = 99.93 %, PPV = 99.98 %, and F1 = 99.95 %, while the results for the challenge database are Se = 99.91 %, PPV = 99.86 %, and F1 = 99.88 %.ConclusionThe results of the test show that the robustness of our proposed whole fusion algorithm was superior to that of other outstanding algorithms for maternal R-wave detection, and is much better than that of single channel maternal R-wave detection algorithms.
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