Objective Hepatocellular carcinoma (HCC) has become a pressing health problem facing the world today due to its high morbidity, high mortality, and late discovery. As a diagnostic criteria of HCC, the exact threshold of Alpha-fetoprotein (AFP) is controversial. Therefore, this study was aimed to systematically estimate the performance of AFP in diagnosing HCC and to clarify its optimal threshold. Methods Medline and Embase databases were searched for articles indexed up to November 2019. English language studies were included if both the sensitivity and specificity of AFP in the diagnosis of HCC were provided. The basic information and accuracy data included in the studies were extracted. Combined estimates for sensitivity and specificity were statistically analyzed by random-effects model using MetaDisc 1.4 and Stata 15.0 software at the prespecified threshold of 400 ng/mL, 200 ng/mL, and the range of 20-100 ng/mL. The optimal threshold was evaluated by the area under curve (AUC) of the summary receiver operating characteristic (SROC). Results We retrieved 29,828 articles and included 59 studies and 1 review with a total of 11,731 HCC cases confirmed by histomorphology and 21,972 control cases without HCC. The included studies showed an overall judgment of at risk of bias. Four studies with AFP threshold of 400 ng/mL showed the summary sensitivity and specificity of 0.32 (95%CI 0.31-0.34) and 0.99 (95%CI 0.98-0.99), respectively. Four studies with AFP threshold of 200 ng/mL showed the summary sensitivity and specificity of 0.49 (95%CI 0.47-0.50) and 0.98 (95%CI 0.97-0.99), respectively. Forty-six studies with AFP threshold of 20-100 ng/mL showed the

We have successfully prepared an optically trapped ultracold mixture of $^{23}$Na and $^{87}$Rb atoms and studied their interspecies Feshbach resonances. Using two different spin combinations, several s-wave and p-wave resonances are identified by observing a high inelastic loss and a temperature rising for both species near resonant magnetic field values. The two s-wave resonances observed below 500 G between atoms in the lowest energy level are possible candidates for Feshbach molecule association. Our results are well characterized by a coupled-channel model and are used refining the ground state interaction potentials between $^{23}$Na and $^{87}$Rb. This work opens up the prospect for preparing ultracold ensembles of ground-state bosonic NaRb molecules which are chemically stable and can provide strong dipolar interactions.Comment: With major modifications, published in Phys. Rev A(R),87, 050702(2013

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We report the creation of ultracold bosonic 23 Na 87 Rb Feshbach molecules via magneto-association. By ramping the magnetic field across an interspecies Feshbach resonance (FR), at least 4000 molecules can be produced out of the near degenerate ultracold mixture. Fast loss due to inelastic atom-molecule collisions is observed, which limits the pure molecule number, after residual atoms removal, to 1700. The pure molecule sample can live for 21.8(8) ms in the optical trap, long enough for future molecular spectroscopy studies toward coherently transferring to the singlet ro-vibrational ground state, where these molecules are stable against chemical reaction and have a permanent electric dipole moment of 3.3 Debye. We have also measured the Feshbach molecule's binding energy near the FR by the oscillating magnetic field method and found these molecules have a large closed-channel fraction.The creation and manipulation of ultracold heteronuclear molecules have received intensive attentions in recent years due to the versatile and promising potential applications [1, 2] of these molecules. With controllable, anisotropic and long range dipole-dipole interactions, they could be used in quantum computation [3,4], quantum simulation [5], precision measurement [6,7] and controlled cold chemistry [8]. So far, the most successful scheme for producing ultracold ground-state dipolar molecule is by associating ultracold atoms near Feshbach resonances (FRs) [9, 10] to form weakly-bound molecules first, followed by a stimulated Raman adiabatic rapid passage (STIRAP) [11] to transfer them to a deeply bound state [12,13]. This has been successfully applied to the 40 K 87 Rb system [14], where near degenerate ground-state dipolar fermionic molecules are created. However, the chemical reaction 2 KRb→ K 2 + Rb 2 is an exoergic process which results in a large inelastic loss, severely limiting the trap lifetime of the KRb molecular gas [15][16][17].Currently, there is a great effort in generalizing the KRb production scheme to other heteronuclear alkali dimers. Creation of Feshbach molecules of RbCs [18], LiNa [19] and NaK [20] were already reported in 2012, and very recently ground-state RbCs molecules were successfully produced [21,22]. In this work, we focus on the bosonic NaRb molecule, which in the absolute ground state is stable against chemical reactions [23] and has a permanent electric dipole moment as large as 3.3 Debye [24]. The ground-state NaRb molecule can be readily polarized with a moderate electric field. For instance, at 5 kV cm −1 the induced dipole moment is already more than 2 Debye. Therefore, it is an appealing system for studying the bosonic quantum gas with strong dipolar interactions. Recently, the double species Bose-Einstein condensates (BECs) of 23 Na and 87 Rb atoms have been produced [25] and their interspecies FRs [26] were also investigated in our group. One of the s-wave resonances between atoms in their lowest hyperfine Zeeman state locates conveniently at a magnetic field B 0 = 347.7 G with a width ...

By imitating in vivo bone mineralization, bone-like apatite-collagen nanocomposites were prepared by chemical phosphorylation of collagen and subsequent biomimetic growth of bone-like nanoapatite on collagen nanofibers. Two steps were employed in the composites preparation. First, the collagen was phosphorylated by chemical treatment, which provides the nucleation sites for bone-like apatite mineralization. The subsequent growth of bone-like nanoapatite on the phosphorylated collagen nanofibers was performed in simulated body fluid (SBF). The characterization of the composites showed that the composites were composed of nanoapatite mineralized collagen nanofibers that exhibit similarity to natural bone in composition and crystal morphology.

We have realized a dual-species Bose-Einstein condensate (BEC) of 23 Na and 87 Rb atoms and observed their immiscibility. Because of the favorable background intra-and inter-species scattering lengths, stable condensates can be obtained via efficient evaporative cooling and sympathetic cooling without the need for fine tuning of the interactions. Our system thus provides a clean platform for studying inter-species interactions driven effects in superfluid mixtures. With a Feshbach resonance, we have successfully created double BECs with largely tunable inter-species interactions and studied the miscible-immiscible phase transition. I.arXiv:1305.7091v2 [cond-mat.quant-gas]

We report the observation of coherent heteronuclear spin dynamics driven by inter-species spinspin interaction in an ultracold spinor mixture, which manifests as periodical and well correlated spin oscillations between two atomic species. In particular, we investigate the magnetic field dependence of the oscillations and find a resonance behavior which depends on both the linear and quadratic Zeeman effects and the spin-dependent interaction. We also demonstrate a unique knob for controlling the spin dynamics in the spinor mixture with species-dependent vector light shifts. Our finds are in agreement with theoretical simulations without any fitting parameters.

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