Aim: To evaluate the outcomes of an apically repositioned flap (ARF) plus xenogeneic collagen matrix (XCM) in augmenting keratinized mucosa width (KMW) around dental implants when compared with ARF plus free gingival grafts (FGG).Materials and methods: Twenty-six participants with at least one site with KMW ≤2 mm were randomized into FGG or XCM group. Clinical examinations were performed at baseline and at 2 and 6 months after surgery, including KMW, keratinized mucosa thickness, gingival index (GI), and probing depth (PD). Post-operative pain and patient satisfaction were also evaluated.Results: At 6 months, FGG attained a greater increase of KMW and thicker mucosa than XCM (4.1 ± 1.6 mm vs. 1.8 ± 1.0 mm, p < .001; 1.7 ± 0.6 mm vs. 1.2 ± 0.3 mm, p < .01). Regarding GI, PD, post-operative pain, aesthetic outcomes, and patient satisfaction, no significant difference could be detected. Moreover, the operation time of XCM group was shorter (60 ± 9 min vs. 39 ± 8 min, p < .001).Conclusions: FGG could result in greater increase of KMW than XCM, though both could increase KMW, maintain peri-implant health, and attain comparable aesthetic outcomes. The use of XCM was associated with reduced operation time. K E Y W O R D Scollagen matrix, dental implants, free gingival graft, keratinized mucosa, randomized controlled trial Clinical RelevanceScientific rationale for study: The clinical efficacy of xenogeneic collagen matrix (XCM) for augmenting keratinized mucosa width (KMW) around implants has been documented. However, limited randomized controlled trials have compared the performance of XCM with free gingival grafts (FGG).Principal findings: FGG resulted in greater increase of KMW, though both XCM and FGG could attain >2 mm KMW. The use of XCM was associated with reduced operation time.Practical implications: FGG is a predictable option in augmenting KMW around implants. XCM could be a valid alternative for patients with a certain amount of keratinized tissue surrounding surgical sites at baseline and low acceptance for soft tissue graft harvesting.Jia-Ping Huang and Jia-Mei Liu contributed equally to this study.

BackgroundWeb-based physician reviews are invaluable gold mines that merit further investigation. Although many studies have explored the text information of physician reviews, very few have focused on developing a systematic topic taxonomy embedded in physician reviews. The first step toward mining physician reviews is to determine how the natural structure or dimensions is embedded in reviews. Therefore, it is relevant to develop the topic taxonomy rigorously and systematically.ObjectiveThis study aims to develop a hierarchical topic taxonomy to uncover the latent structure of physician reviews and illustrate its application for mining patients’ interests based on the proposed taxonomy and algorithm.MethodsData comprised 122,716 physician reviews, including reviews of 8501 doctors from a leading physician review website in China (haodf.com), collected between 2007 and 2015. Mixed methods, including a literature review, data-driven-based topic discovery, and human annotation were used to develop the physician review topic taxonomy.ResultsThe identified taxonomy included 3 domains or high-level categories and 9 subtopics or low-level categories. The physician-related domain included the categories of medical ethics, medical competence, communication skills, medical advice, and prescriptions. The patient-related domain included the categories of the patient profile, symptoms, diagnosis, and pathogenesis. The system-related domain included the categories of financing and operation process. The F-measure of the proposed classification algorithm reached 0.816 on average. Symptoms (Cohen d=1.58, Δu=0.216, t=229.75, and P<.001) are more often mentioned by patients with acute diseases, whereas communication skills (Cohen d=−0.29, Δu=−0.038, t=−42.01, and P<.001), financing (Cohen d=−0.68, Δu=−0.098, t=−99.26, and P<.001), and diagnosis and pathogenesis (Cohen d=−0.55, Δu=−0.078, t=−80.09, and P<.001) are more often mentioned by patients with chronic diseases. Patients with mild diseases were more interested in medical ethics (Cohen d=0.25, Δu 0.039, t=8.33, and P<.001), operation process (Cohen d=0.57, Δu 0.060, t=18.75, and P<.001), patient profile (Cohen d=1.19, Δu 0.132, t=39.33, and P<.001), and symptoms (Cohen d=1.91, Δu=0.274, t=62.82, and P<.001). Meanwhile, patients with serious diseases were more interested in medical competence (Cohen d=−0.99, Δu=−0.165, t=−32.58, and P<.001), medical advice and prescription (Cohen d=−0.65, Δu=−0.082, t=−21.45, and P<.001), financing (Cohen d=−0.26, Δu=−0.018, t=−8.45, and P<.001), and diagnosis and pathogenesis (Cohen d=−1.55, Δu=−0.229, t=−50.93, and P<.001).ConclusionsThis mixed-methods approach, integrating literature reviews, data-driven topic discovery, and human annotation, is an effective and rigorous way to develop a physician review topic taxonomy. The proposed algorithm based on Labeled-Latent Dirichlet Allocation can achieve impressive classification results for mining patients’ interests. Furthermore, the mining results reveal marked differences in patients’ inter...

Introduction This study presents an empirical method to model the high-energy photon beam percent depth dose (PDD) curve by using the home-generated buildup function and tail function (buildup-tail function) in radiation therapy. The modeling parameters n and μ of buildup-tail function can be used to characterize the Collimator Scatter Factor (Sc) either in a square field or in the different individual upper jaw and lower jaw setting separately for individual monitor unit check. Methods and materials The PDD curves for four high-energy photon beams were modeled by the buildup and tail function in this study. The buildup function was a quadratic function in the form of dd2+n with the main parameter of d (depth in water) and n, while the tail function was in the form of e−μd and was composed by an exponential function with the main parameter of d and μ. The PDD was the product of buildup and tail function, PDD = dd2+n·e−μd. The PDD of four-photon energies was characterized by the buildup-tail function by adjusting the parameters n and μ. The Sc of 6 MV and 10 MV can then be expressed simply by the modeling parameters n and μ. Results The main parameters n increases in buildup-tail function when photon energy increased. The physical meaning of the parameter n expresses the beam hardening of photon energy in PDD. The fitting results of parameters n in the buildup function are 0.17, 0.208, 0.495, 1.2 of four-photon energies, 4 MV, 6 MV, 10 MV, 18 MV, respectively. The parameter μ can be treated as attenuation coefficient in tail function and decreases when photon energy increased. The fitting results of parameters μ in the tail function are 0.065, 0.0515, 0.0458, 0.0422 of four-photon energies, 4 MV, 6 MV, 10 MV, 18 MV, respectively. The values of n and μ obtained from the fitted buildup-tail function were applied into an analytical formula of Sc = nE(S)0.63μE to get the collimator to scatter factor Sc for 6 and 10 MV photon beam, while nE, μE, S denotes n, μ at photon energy E of field size S, respectively. The calculated Sc were compared with the measured data and showed agreement at different field sizes to within ±1.5%. Conclusions We proposed a model incorporating a two-parameter formula which can improve the fitting accuracy to be better than 1.5% maximum error for describing the PDD in different photon energies used in clinical setting. This model can be used to parameterize the Sc factors for some clinical requirements. The modeling parameters n and μ can be used to predict the Sc in either square field or individual jaws opening asymmetrically for treatment monitor unit double-check in dose calculation. The technique developed in this study can also be used for systematic or random errors in the QA program, thus improves the clinical dose computation accuracy for patient treatment.

Liposarcoma (LPS) is the most common soft tissue sarcoma. Myxoid LPS (MLPS) is the second most common subtype of LPS and accounts for 25% to 50% of all LPSs. Like most other soft tissue sarcomas, the mainstay of treatment for LPS is inevitably surgery. Multidisciplinary approaches, including surgery, chemotherapy, and radiotherapy, have been successful in the treatment of LPS during the last three decades. Even so, recurrence of LPS remains challenging. Carbon ion beams produce increased energy deposition at the end of their range to form a Bragg peak while minimizing irradiation damage to surrounding tissues, which facilitates more precise dosage and localization than that achieved with photon beams. Furthermore, carbon ion beams have high relative biologic effectiveness. We herein describe a patient who developed recurrent MLPS in the right calf after two surgeries and underwent carbon ion radiotherapy (CIRT), achieving complete disappearance of the tumor. The patient developed Grade 1 radiation dermatitis 30 days after CIRT, but no other acute toxicities were observed. The tumor had completely disappeared by 120 days after CIRT, and the patient remained disease-free for 27 months after CIRT. The CARE guidelines were followed in the reporting of this case.

Aim. To investigate the value of neoadjuvant chemotherapy combined with 3D-image-guided afterloading intracavitary radiotherapy in locally advanced cervical cancer (LACC). Methods. Patients with cervical cancer admitted to our hospital from January 1, 2020 to January 1, 2021 were retrieved and analyzed. Cases treated with neoadjuvant chemotherapy and 3D-image-guided afterloading intracavitary radiotherapy were assigned into the observation group (OG), while cases with neoadjuvant chemotherapy alone were assigned into the control group (CG). The short-term effects were determined by RECIST 1.1. Total effective rate TR = complete   remission   CR + partial   remission   PR . The serum levels of squamous epithelial cell carcinoma antigen (SCC-Ag), glycoantigen 125 (CA125), carcinoembryonic antigen (CEA), and vascular endothelial growth factor (VEGF) were assessed. In view of the difference between tumor markers and diameters before and after treatment, the correlation between them was analyzed by Pearson test. The adverse events were compared, and the amount of operative bleeding and operation time were evaluated. Cox regression analysis was conducted to assess the influencing factors of 1-year disease-free survival time. Results. Sixty-seven patients were retrieved, including 30 cases in the OG and 37 cases in the CG. There were no significant differences in age, pathological type, tumor size, FIGO stage, past medical history, or smoking history between the two groups ( P > 0.05 ). The TR of patients in the OG was higher than that in the CG ( P < 0.05 ). The SCC-Ag, CA125, CEA, and VEGF levels in the OG decreased markedly after treatment ( P < 0.001 ). The difference in SCC-Ag, CA125, CEA, and VEGF was positively correlated with the difference in tumor diameter before and after treatment ( P < 0.05 ). The incidence of adverse events revealed no obvious difference between the OG and CG ( P > 0.05 ). Cox regression analysis showed that FIGO stage and treatment regimens were independent prognostic factors for 1-year disease-free survival ( P < 0.05 ). Conclusion. Neoadjuvant chemotherapy combined with 3D-image-guided afterloading intracavitary radiotherapy can improve the TR rate and 1-year disease-free survival of LACC patients without increasing the incidence of adverse events.