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In this paper, the combination of efficient sixth-order compact finite difference scheme (E-CFDS6) based proper orthogonal decomposition and Strang splitting method (E-CFDS6-SSM) is constructed for the numerical solution of the multi-dimensional parabolic equation (MDPE). For this purpose, we first develop the CFDS6 to attain a high accuracy for the one-dimensional parabolic equation (ODPE). Then, by the Strang splitting method, we have converted the MDPE into a series of one-dimensional ODPEs successfully, which is easier to implement and program with CFDS6 than an alternating direction implicit method. Finally, we employ proper orthogonal decomposition techniques to improve the computational efficiency of CFDS6 and build the E-CFDS6-SSM with fewer unknowns and sufficiently high accuracy.Six numerical examples are presented to demonstrate that the E-CFDS6-SSM not only can largely alleviate the computational load but also hold a high accuracy and simplify the process of the program for the numerical solution of MDPE.