Circulating tumor cell (CTC) as an important component in "liquid biopsy" holds crucial clinical relevance in cancer prognosis, treatment efficiency evaluation, prediction and potentially early detection. Here, we present a Fiber-optic Array Scanning Technology (FAST) that enables antigen-agnostic, size-agnostic detection of CTC. By immunofluorescence staining detection of a combination of a panel of markers, FAST technology can be applied to detect rare CTC in non-small cell lung cancer (NSCLC) setting with high sensitivity and specificity. In combination with Automated Digital Microscopy (ADM) platform, companion markers on CTC such as Vimentin and Programmed death-ligand 1 (PD-L1) can also be analyzed to further characterize these CTCs. FAST data output is also compatible with downstream single cell picking platforms. Single cell can be isolated post ADM confirmation and used for "actionable" genetic mutations analysis.
Bone morphogenetic protein belongs to the transforming growth factor beta superfamily, is a unique ectopic cartilage and bone inducing activity of acidic protein. As one of the members of BMPs family, the formation and development of BMP4 in many organizations. In ocular tissue, BMP4 not only promotes the differentiation and development of different eye cells, but also plays an important role in ocular diseases. In this study, the recent advances in the study of BMP4 in ocular tissues are summarized and the function of BMP4 in different developmental stages of eye is briefly reviewed.
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