The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. For that reason, iron complexes find less application in photochemical organic synthesis. Through iron photocatalysis, a mild and effective protocol for decarboxylative C–C and C–N bond formation has been achieved. The carboxylic acids readily undergo radical decarboxylation in the presence of Fe2(SO4)3 and di‐(2‐picolyl)amine under visible light irradiation. The resulting alkyl radicals then react with Michael acceptors or azodicarboxylates to furnish the adducts.
This paper deals with a deep circular tunnel excavated in infinite homogeneous and isotropic elastoviscoplastic rock mass subjected to a hydrostatic initial stresses. The tunnel is divided into the initial plastic, viscoplastic, and elastic zones. By combining the generalized Bingham model with Mohr-Coulomb yield criteria, analytical solutions of the circular tunnel are derived with the consideration of non-associated flow rule and elasto-viscoplasticity. The initial plastic zone is defined as the instantaneous change of rock mass excavation. Based on the initial plastic zone, the stresses in viscoplastic zone are transferred to the deep surrounding rock with time due to the initial earth stresses. The results are compared with the elastic-brittle solution at static conditions, and the solutions of this paper are validated. Moreover, the presented results shows that the stress and displacement of the surrounding rock varies with time, and the solutions can be obtained at different instants of time.
PurposeHigh mobility group box-1 (HMGB1) is a proinflammatory, DAMP protein that participates in many pathological conditions. In this study, we evaluated the usability of CSF HMGB1 as a biomarker for the diagnosis of tuberculous meningitis (TBM).MethodsA total of 59 TBM patients and 169 control patients were included in our study. CSF samples were obtained and analyzed for HMGB1 using a commercial ELISA kit.ResultsThe mean CSF HMGB1 was 19.36 ng/ml in TBM patients (n = 59) versus 3.12 ng/ml in non-TB meningitis patients (n = 30), 2.13 ng/ml in patients with extra neural tuberculosis (n = 73), and 1.06 ng/m in controls (n = 66). According to the receiver operator characteristic curves, a cut-off value of 3.4 ng/ml was calculated, indicating that the sensitivity and specificity of CSF HMGB1 alone in diagnosis of TBM were 61.02 and 89.94 %, respectively. In patients with extra neural tuberculosis and a high risk of TBM, CSF HMGB1 seemed to be a good candidate for early differential diagnosis of TBM at the cut-off value of 3.8 ng/ml, when the sensitivity and specificity were 79.49 and 94.52 % respectively.ConclusionOur finding may prove to be clinically useful, because CSF HMGB1 ELISA can be performed in almost all clinical laboratories, especially when sophisticated technologies are either time consuming or unavailable.
The cracks and holes in underground engineering are the critical factors that cause the instability of the surrounding rock. It is helpful to control the stability of surrounding rock to study the samples with combined defects of cracks and holes. In this study, PFC 2D is used to analyze the numerical models. Seven combined models of single circular hole and double cracks with different angles are established, and the fracture angle varies from 0° to 90° with an interval of 15°. First, uniaxial compression experiments and numerical simulations are carried out in the 0° defect combination model, and the microscopic parameters of PFC 2D are determined. Then, the numerical simulations of seven defect models under uniaxial compression are carried out, and the crack development law and acoustic emission characteristics of different defect combination models are studied. The failure modes, mechanical behavior, and stress states are studied. The displacement vector distributions of different defect combination models are analyzed; it is found that there are three main types of macro cracks in the defect combination samples. The results show that the combined defects reduce the strength of the model. Meanwhile, the distributions of the stress and displacement are changed by the cracks with different angles in the defective models.
This paper presents an adaptive path following control law to steer underactuated ships along a predefined path at a constant forward speed with uncertain parameters due to changes of added mass matrices. The proposed controller is based on analytic model predictive control and model reference adaptive control. The SerretFrenet frame is used to describe the ship dynamics. The analytic model predictive control provides a systematic method rather than try-and-error method to get appropriate control parameters to guarantee the stability of the closed-loop system, and the well-defined relative degree is guaranteed by introducing output-redefinition. An identification algorithm based on model reference adaptive control is used to identify the uncertain parameters. Numerical simulations are provided to demonstrate the validity of the proposed control law.
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