BackgroundOptical imaging (OI) techniques such as bioluminescence and fluorescence imaging have been widely used to track diseases in a non-invasive manner within living subjects. These techniques generally require bioluminescent and fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for in vivo molecular OI.Methodology/Principal FindingsBy taking the advantages of low energy window of light (1.2–3.1 eV, 400–1000 nm) resulting from radiation, radionuclides that emit charged particles such as β+ and β− can be successfully imaged with an OI instrument. In vivo optical images can be obtained for several radioactive probes including 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), Na18F, Na131I, 90YCl3 and a 90Y labeled peptide that specifically target tumors.Conclusions/SignificanceThese studies demonstrate generalizability of radioactive OI technique. It provides a new molecular imaging strategy and will likely have significant impact on both small animal and clinical imaging.
The fusion excitation function of 40 Ca + 40 Ca has been measured from well above the Coulomb barrier, down to low energies where the cross section is as small as ≃20 µb, and the astrophysical S factor possibly reaches a maximum vs. energy.
This is an exciting time for the study of r-process nucleosynthesis. Recently, a neutron star merger GW170817 was observed in extraordinary detail with gravitational waves and electromagnetic radiation from radio to γ rays. The very red color of the associated kilonova suggests that neutron star mergers are an important r-process site. Astrophysical simulations of neutron star mergers and core collapse supernovae are making rapid progress. Detection of both, electron neutrinos and antineutrinos from the next galactic supernova will constrain the composition of neutrino-driven winds and provide unique nucleosynthesis information. Finally FRIB and other rare-isotope beam facilities will soon have dramatic new capabilities to synthesize many neutron-rich nuclei that are involved in the r-process. The new capabilities can significantly improve our understanding of the r-process and likely resolve one of the main outstanding problems in classical nuclear astrophysics.However, to make best use of the new experimental capabilities and to fully interpret the results, a great deal of infrastructure is needed in many related areas of astrophysics, astronomy, and nuclear theory. We will place these experiments in context by discussing astrophysical simulations and observations of r-process sites, observations of stellar abundances, galactic chemical evolution, and nuclear theory for the structure and reactions of very neutron-rich nuclei. This review paper was initiated at a three-week International Collaborations in Nuclear Theory program in June 2016 where we explored promising r-process experiments and discussed their likely impact, and their astrophysical, astronomical, and nuclear theory context.
The fusion cross section for 12 C+ 13 C has been measured down to Ec.m.=2.6 MeV at which the cross section is of the order of 20 nb. By comparing the cross sections for the three carbon isotope systems, 12 C+ 12 C, 12 C+ 13 C and 13 C+ 13 C, it is found that the cross sections for 12 C+ 13 C and 13 C+ 13 C provide an upper limit for the fusion cross section of 12 C+ 12 C over a wide energy range. After calibrating the effective nuclear potential for 12 C+ 12 C using the 12 C+ 13 C and 13 C+ 13 C fusion cross sections, it is found that a coupled-channels calculation with the Incoming Wave Boundary Condition (IWBC) is capable of predicting the major peak cross sections in 12 C+ 12 C. A qualitative explanation for this upper limit is provided by the Nogami-Imanishi model and level density differences among the compound nuclei. It is found that the strong resonance found at 2.14 MeV in 12 C+ 12 C exceeds this upper limit by a factor of more than 20. The preliminary result from the most recent measurement shows a much smaller cross section at this energy which agrees with our predicted upper limit.
Sm (25). We prepared spectroscopic alpha sources (20-100 μg) from the three activations and counted them during several months using a silicon surface-barrier detector at Kanazawa University (Fig. 1, 25 Galactic-disk enrichment in low-metallicity gas (Fig. 3). This reduces the age of late events (≥ 50 Ma) (age is measured in this work relative to the birth of the solar system) but has a minor effect on earlier events (Table 1). Samarium-146 observations in terrestrial samples can be divided into two groups: (i) most terrestrial rocks display a 142 Nd/ 144 Nd ratio higher by ~18 parts per million (ppm) than CHUR (9) and (ii) anomalies in the 142 Nd/ 144 Nd ratio relative to the terrestrial standard, both positive, in rocks from Greenland and Australia (2,10), and negative, in rocks from Northern Quebec (2,11).
Fusion data for 13 C+ 13 C, 12 C+ 13 C and 12 C+ 12 C are analyzed by coupled-channels calculations that are based on the M3Y+repulsion, double-folding potential. The fusion is determined by ingoingwave-boundary conditions (IWBC) that are imposed at the minimum of the pocket in the entrance channel potential. Quadrupole and octupole transitions to low-lying states in projectile and target are included in the calculations, as well as mutual excitations of these states. The effect of oneneutron transfer is also considered but the effect is small in the measured energy regime. It is shown that mutual excitations to high-lying states play a very important role in developing a comprehensive and consistent description of the measurements. Thus the shapes of the calculated cross sections for 12 C+ 13 C and 13 C+ 13 C are in good agreement with the data. The fusion cross sections for 12 C+ 12 C determined by the IWBC are generally larger than the measured cross sections but they are consistent with the maxima of some of the observed peak cross sections. They are therefore expected to provide an upper limit for the extrapolation into the low-energy regime of interest to astrophysics.
13N͑p , ␥͒ 14 O is one of the key reactions which trigger the onset of the hot CNO cycle. This transition occurs when the proton capture rate on 13 N is faster, due to increasing stellar temperature ͑ജ10 8 K͒, than the 13 N -decay rate. The rate of this reaction is dominated by the resonant capture through the first excited state of 14 O ͑E r = 0.528 MeV͒. However, through constructive interference, direct capture below the resonance makes a non-negligible contribution to the reaction rate. We have determined this direct contribution by measuring the asymptotic normalization coefficient for 14 O → 13 N+ p. In our experiment, an 11.8 MeV/ nucleon 13 N radioactive beam was used to study the 14 N͑ 13 N, 14 O͒ 13 C peripheral transfer reaction, and the asymptotic normalization coefficient, ͑C p 1/2 14 O ͒ 2 = 29.0± 4.3 fm −1 , was extracted from the measured cross section. The radiative capture cross section was estimated using an R-matrix approach with the measured asymptotic normalization coefficient and the latest resonance parameters. We find the S factor for 13 N͑p , ␥͒ 14 O to be larger than previous estimates. Consequently, the transition from the cold to hot CNO cycle for novae would be controlled by the slowest proton capture reaction 14 N͑p , ␥͒ 15 O.
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