A novel palladium-catalyzed regiocontrollable hydroarylation reaction of allenamides with B2pin2/H2O has been disclosed.

This work reports the copper(i)-catalyzed 5-exo-trig radical cyclization/borylation of alkyl halides bearing an alkene moiety, during which a C-C bond and a C-B bond were formed in one step. Various functionalized pyrrolidine derivatives bearing a quaternary carbon center were obtained, and they showed good functional group tolerance and high chemoselectivity. This transformation was highly efficient and could be finished in 20 minutes. A radical mechanism has been proposed.

A mild and efficient type of Pd/Cu-catalyzed allenamide allyl acetate reaction with terminal alkynes affording polyfunctionalized 2,3-dihydropyrrole derivatives is reported. Allenamide substrates went through two π-allyl palladium complex processes, and then it was trapped by terminal alkynes on the distal position via a Sonogashira reaction. Two new Csp 3 À Csp 2 and Csp 3 À Csp bonds were efficiently constructed in one pot.

The Octahydro-1H-cyclopenta[c]pyridine Skeletons exist in a broad spectrum of bioactive natural products, and the development of efficient and convenient protocols to construct this skeleton remains a challenging task. Herein, we...

A new cycloisomerisation of Z-1-iodo-4-N-methylbenzenesulfonyl-1,6-enynes to functionalized pyrroles was realized in the presence of an organomolecule (4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine) and KOtBu.