Urban boundaries, an essential property of cities, are widely used in many urban studies. However, extracting urban boundaries from satellite images is still a great challenge, especially at a global scale and a fine resolution. In this study, we developed an automatic delineation framework to generate a multi-temporal dataset of global urban boundaries (GUB) using 30 m global artificial impervious area (GAIA) data. First, we delineated an initial urban boundary by filling inner non-urban areas of each city. A kernel density estimation approach and cellular-automata based urban growth modeling were jointly used in this step. Second, we improved the initial urban boundaries around urban fringe areas, using a morphological approach by dilating and eroding the derived urban extent. We implemented this delineation on the Google Earth Engine platform and generated a 30 m resolution global urban boundary dataset in seven representative years (i.e. 1990, 1995, 2000, 2005, 2010, 2015, and 2018). Our extracted urban boundaries show a good agreement with results derived from nighttime light data and human interpretation, and they can well delineate the urban extent of cities when compared with high-resolution Google Earth images. The total area of 65 582 GUBs, each of which exceeds 1 km2, is 809 664 km2 in 2018. The impervious surface areas account for approximately 60% of the total. From 1990 to 2018, the proportion of impervious areas in delineated boundaries increased from 53% to 60%, suggesting a compact urban growth over the past decades. We found that the United States has the highest per capita urban area (i.e. more than 900 m2) among the top 10 most urbanized nations in 2018. This dataset provides a physical boundary of urban areas that can be used to study the impact of urbanization on food security, biodiversity, climate change, and urban health. The GUB dataset can be accessed from http://data.ess.tsinghua.edu.cn.

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Abstract:The housing market in Chinese metropolises have become inflated significantly over the last decade. In addition to an economic upturn and housing policies that have potentially fueled the real estate bubble, factors that have contributed to the spatial heterogeneity of housing prices can be dictated by the amenity value in the proximity of communities, such as accessibility to business centers and transportation hubs. In the past, scholars have employed the hedonic pricing model to quantify the amenity value in relation to structural, locational, and environmental variables. These studies, however, are limited by two methodological obstacles that are relatively difficult to overcome. The first pertains to difficulty of data collection in regions where geospatial datasets are strictly controlled and limited. The second refers to the spatial autocorrelation effect inherent in the hedonic analysis. Using Beijing, China as a case study, we addressed these two issues by (1) collecting residential housing and urban amenity data in terms of Points of Interest (POIs) through web-crawling on open access platforms; and (2) eliminating the spatial autocorrelation effect using the Eigenvector Spatial Filtering (ESF) method. The results showed that the effects of nearby amenities on housing prices are mixed. In other words, while proximity to certain amenities, such as convenient parking, was positively correlated with housing prices, other amenity variables, such as supermarkets, showed negative correlations. This mixed finding is further discussed in relation to community planning strategies in Beijing. This paper provides an example of employing open access datasets to analyze the determinants of housing prices. Results derived from the model can offer insights into the reasons for housing segmentation in Chinese cities, eventually helping to formulate effective urban planning strategies and equitable housing policies.

Emerging evidence suggests a resurgence of COVID-19 in the coming years. It is thus critical to optimize emergency response planning from a broad, integrated perspective. We developed a mathematical model incorporating climate-driven variation in community transmissions and movement-modulated spatial diffusions of COVID-19 into various intervention scenarios. We find that an intensive 8-wk intervention targeting the reduction of local transmissibility and international travel is efficient and effective. Practically, we suggest a tiered implementation of this strategy where interventions are first implemented at locations in what we call the Global Intervention Hub, followed by timely interventions in secondary high-risk locations. We argue that thinking globally, categorizing locations in a hub-and-spoke intervention network, and acting locally, applying interventions at high-risk areas, is a functional strategy to avert the tremendous burden that would otherwise be placed on public health and society.

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Annexin A1 is a member of a large superfamily of glucocorticoid-regulated, calcium- and phospholipid-binding proteins. Our previous studies have shown that the abnormal expression of Annexin A1 is related to the occurrence and development of nasopharyngeal carcinoma (NPC). To understand the roles of Annexin A1 in the tumorigenesis of NPC, targeted proteomic analysis was performed on Annexin A1-associated proteins from NPC cells. We identified 436 proteins associated with Annexin A1, as well as two Annexin A1-interacted key proteins, S100A9 and Vimentin, which were confirmed by co-immunoprecipitation. Gene function classification revealed that the Annexin A1-associated proteins can be grouped into 21 clusters based on their molecular functions. Protein–protein interaction analysis indicated that Annexin A1 /S100A9/Vimentin interactions may be involved in the invasion and metastasis of NPC because they can form complexes in NPC cells. The down-regulation of Annexin A1 in NPC may lead to the overexpression of S100A9/Vimentin, which may increase the possibility of the invasion ability of NPC cells by adjusting the function of cytoskeleton proteins. Results suggested that the biological functions of Annexin A1 in NPC were diverse, and that Annexin A1 can inhibit the in vitro invasive ability of NPC cells through Annexin A1 /S100A9/Vimentin interaction.

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